34015-83-3Relevant academic research and scientific papers
Design and Synthesis of Novel 1a,3,4-Oxadiazole Derivatives as Cytotoxic Agents: A Combined Experimental and Docking Study
Bera, R.,Perla, P.,Seelam, N.
, p. 924 - 934 (2020)
Abstract: A novel series of 3,5-disubstituted-1a,3,4-oxadiazole derivatives was synthesized and screened for in vitro anticancer activity. The newly synthesized compounds were characterized by 1H, 13C NMR, IR spectroscopy and mass sp
Design and synthesis of oxaprozin-1,3,4-oxadiazole hybrids as potential anticancer and antibacterial agents
Anantaraju, Hasitha Shilpa,Anireddy, Jaya Shree,Balasubramanian, Sridhar,Banothu, Venkanna,Kuntala, Naveen,Perumal, Yogeeswari,Polkam, Naveen,Rayam, Parsharamulu
, (2020)
In the present study, we report design, synthesis and screening of new novel 5-substituted-2-mercapto-1,3,4-oxadiazole analogues appended to oxaprozin for their in vitro anticancer and antibacterial activity. The synthesised compounds were characterized using various spectroscopic techniques. Furthermore, the structure of 5b (2-(2-[4,5-diphenyloxazol-2-yl]ethyl)-5-(ethylthio)-1,3,4-oxadiazole) was unequivocally confirmed by X-ray analysis. Among the series 5c (2-(2-[4,5-diphenyloxazol-2-yl]ethyl)-5-(propylthio)-1,3,4-oxadiazole) showed most promising anticancer activity against A549 cancer cell line and all the reported analogues manifested satisfactory safety profiles against human normal cell line HEK293T. The products exhibited good antibacterial activity and among the tested 5j (2-(2-[4,5-diphenyloxazol-2-yl]ethyl)-5-([4-fluorobenzyl]thio)-1,3,4-oxadiazole) exhibited most potent.
