34035-42-2Relevant academic research and scientific papers
Tricyclic imidazole derivatives
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, (2008/06/13)
New tricyclic fused imidazole derivatives of the general formula (I), SPC1 wherein R1 stands for hydrogen or hydroxy, n is equal to zero or one, m is equal to zero, one or two, A stands for a group of the general formula (II), EQU1 wherein R2 represents hydrogen or hydroxy, R3 represents hydrogen or amino, or Q and Z each stand for nitrogen or a =C-- group, or A stands for a group of the general formula (III), EQU2 wherein R4 and R5 each represent hydrogen, methyl, chlorine or nitro, Were prepared by reacting a compound of the general formula (IV) SPC2 wherein A and n each have the same meanings as defined above, with a compound of the general formula (V), EQU3 wherein X stands for halogen, R6 stands for hydrogen and R7 stands for a group of the general formula (VI), in which m and X each have the same meanings as defined above, or R6 and R7 together stand for oxygen. The reaction is carried out optionally in the presence of a base. The compounds of the general formula (I) can be converted into their acid addition salts. The compounds of the general formula (I) as well as their acid addition salts exert antipyretic and antiphlogistic activities, inhibit the reproduction of viruses, and exert a protecting effect against albumine shock.
