34037-27-9Relevant academic research and scientific papers
Non-natural 2: H -azirine-2-carboxylic acids: An expedient synthesis and antimicrobial activity
Sakharov, Pavel A.,Koronatov, Alexander N.,Khlebnikov, Alexander F.,Novikov, Mikhail S.,Glukharev, Artem G.,Rogacheva, Elizaveta V.,Kraeva, Liudmila A.,Sharoyko, Vladimir V.,Tennikova, Tatiana B.,Rostovskii, Nikolai V.
, p. 37901 - 37905 (2019)
Non-natural 2H-azirine-2-carboxylic acids were obtained in high yields by FeCl2-catalyzed isomerization of 5-chloroisoxazoles to azirine-2-carbonyl chlorides followed by their hydrolysis. The 3-aryl- and 3-heteroaryl-substituted acids are stable during prolonged storage, exhibit antibacterial activity against ESKAPE pathogens and show a low level of cytotoxicity.
