34041-75-3Relevant academic research and scientific papers
Scandium(III) triflate mediated intramolecular ring expansion of aziridines: A direct access to 4-aryltetrahydroisoquinolines
Satyanarayana, Tummanapalli,Muthuraman, Parthasarathy,Vangapandu, Dhanunjaya Naidu,Majumder, Supriyo
, p. 6787 - 6790 (2014)
A novel, high yielding facile synthesis of 4-substituted tetrahydroisoquinolines has been developed by employing scandium(III) triflate mediated intramolecular ring expansion of aziridines. The meta-substituted electron-donating group on the benzene ring facilitates trapping of an in situ generated benzyl carbenium ion cation leading to the formation of tetrahydroisoquinolines.
