34064-86-3

Usage

Uses

Used in Pharmaceutical Industry:
3-PIPERAZIN-1-YL-PROPIONITRILE is used as a key intermediate in the synthesis of various drugs and pharmaceutical products due to its chemical reactivity and structural properties that facilitate the creation of diverse medicinal compounds.
Used in Drug Discovery and Development:
3-PIPERAZIN-1-YL-PROPIONITRILE is utilized as a potential candidate in drug discovery and development because of its inherent biological activity, which makes it a valuable component in the design and synthesis of new medications intended for a wide range of therapeutic applications.

InChI:InChI=1/C7H13N3/c8-2-1-5-10-6-3-9-4-7-10/h9H,1,3-7H2

Upstream product

• 110-85-0 piperazine 
• 107-13-1 acrylonitrile 

Downstream Products

• 916140-59-5 3-[4-(3-diphenylaminopropyl)piperazin-1-yl]propionitrile 
• 916140-66-4 3-[4-(3-diphenylaminopropyl)piperazin-1-yl]propylamine 
• 713145-08-5 3-{6-[4-(2-cyano-ethyl)-piperazin-1-yl]-[1,7]naphthyridin-8-yl}-benzonitrile 
• 1415986-50-3 3-[4-({2-[4-(trifluoromethyl)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl}sulfonyl)piperazin-1-yl]propanenitrile 
• 1258411-08-3 C₂₂H₂₄ClN₉OS 

Relevant academic research and scientific papers

Thioamides from 5-arylfurfural and monosubstituted piperazine derivatives (Wilgerodt-Kindler reaction)

Interaction of 5-arylfurfurals or arylaldehydes with secondary amines (monosubstituted piperazines, morpholine, piperidine) and sulfur under conditions of Wilgerodt-Kindler reaction provided N-substituted thioamides of 5-arylfuran-2-carboxylic and benzoic acids.

2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY

Compound of formula (I′) or (I′′) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of mammalian kinase enzyme activity, including ROR1 tyrosine kinase activity and may be used in the treatment of disorders associated with such activity.

Aqueous aza-michael reaction of conjugated alkenes: Toward spermine

An aqueous aza-Michael reaction is efficiently achieved with excellent conversions without any additives. The method works very well on a molar scale with selectively for aliphatic amines. An intermediate for spermine is also made by this green process.

Triethylammonium acetate (TEAA): A recyclable inexpensive ionic liquid promotes the chemoselective aza- and thia-Michael reactions

A new, highly efficient, inexpensive, recyclable, mild, convenient, and green protocol for chemoselective aza/thia-Michael addition reactions of amines/thiols to α,β-unsaturated compounds using triethylammonium acetate (TEAA) ionic liquid was developed. The catalyst can be recycled ten times and obviate the need for toxic and expensive catalysts.

Synthesis, characterization and in vitro biological studies of novel cyano derivatives of N-alkyl and N-aryl piperazine

Cyano derivatives of N-alkyl and N-aryl piperazine have been synthesized and screened for antibacterial and antifungal activities. All the synthesized compounds showed the antibacterial activity against pathogenic strains of Staphylococcus aureus (MTCCB 737), Pseudomonas aeruginosa (MTCCB 741), Streptomyces epidermidis (MTCCB 1824) and Escherichia coli (MTCCB 1652) and antifungal activity against pathogenic strains of Aspergillus fumigatus (ITCC 4517), Aspergillus flavus (ITCC 5192) and Aspergillus niger (ITCC 5405). All compounds showed mild to moderate antimicrobial activity. However, compounds 3c, 4a and 6 showed potent antibacterial activity against pathogenic strains used in the study. Compounds 3a, 3b, 4b, and 4d showed mild to moderate antifungal activity against Aspergillus pathogenic strains. The compounds reported in this study were assessed for there cytotoxicity using MTT colorimetric assay on Hela cells. All the compounds showed cell viability more than the control drug gentamicin, with compound 2 having highest i.e. 95% cell viability.

Ceric ammonium nitrate catalyzed aza-Michael addition of aliphatic amines to α,β-unsaturated carbonyl compounds and nitriles in water

Ceric ammonium nitrate (3 mol%) efficiently catalyzes the aza-Michael reaction of amines with α,β-unsaturated carbonyl compounds in water to produce the corresponding β-amino carbonyl compounds in good to excellent yields (55-99%) for most of the compounds under mild conditions. The reaction is procedurally simple and displays limited chemoselectivity, as aromatic amines were found to be unreactive. Georg Thieme Verlag Stuttgart.

Cu-nanoparticles: A chemoselective catalyst for the aza-Michael reactions of N-alkyl- and N-arylpiperazines with acrylonitrile

A novel method for effecting the aza-Michael reactions of N-alkyl- and N-arylpiperazines with acrylonitrile using Cu-nanoparticles is described. The method features the use of 10 mol % Cu (14-17 nm) nanoparticles under mild reaction conditions to afford the addition products in good to excellent yields. The Cu-nanoparticles selectively catalysed the aza-Michael reaction of N-alkyl- and N-arylpiperazines in the presence of aromatic amino or aliphatic hydroxy groups.