34064-86-3

Basic information

• Product Name: 3-PIPERAZIN-1-YL-PROPIONITRILE
• Synonyms: TIMTEC-BB SBB010119;RARECHEM AH CK 0175;3-(1-PIPERAZINYL)-PROPIONITRIL;3-(1-PIPERAZINYL)PROPIONITRILE;1-(2-CYANOETHYL)PIPERAZINE;3-PIPERAZIN-1-YLPROPANENITRILE;3-PIPERAZIN-1-YL-PROPIONITRILE;3-PIPERAZINOPROPIONITRILE
• CAS NO: 34064-86-3
• Molecular Formula: C₇H₁₃N₃
• Molecular Weight: 139.2
• Product Categories: piperazines;Building Blocks;C4 to C8;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 34064-86-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 95-98°C/3mm
• Flash Point: 125.062 °C
• Appearance: /
• Density: 0.987 g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: n20/D 1.493
• CAS DataBase Reference: 3-PIPERAZIN-1-YL-PROPIONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PIPERAZIN-1-YL-PROPIONITRILE(34064-86-3)
• EPA Substance Registry System: 3-PIPERAZIN-1-YL-PROPIONITRILE(34064-86-3)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• RIDADR: UN3276
• WGK Germany: 3
• F: 10-34
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 34064-86-3(Hazardous Substances Data)

Usage

General Description

3-PIPERAZIN-1-YL-PROPIONITRILE is a chemical compound with the molecular formula C8H15N3. It is commonly used in the pharmaceutical industry as a key intermediate in the synthesis of various drugs and pharmaceutical products. 3-PIPERAZIN-1-YL-PROPIONITRILE is a piperazine derivative with a propionitrile functional group, making it useful in the development of medications for a wide range of therapeutic applications. Additionally, it has been found to exhibit biological activity, making it a potential candidate for further exploration in drug discovery and development. Overall, 3-PIPERAZIN-1-YL-PROPIONITRILE plays a critical role in the pharmaceutical industry and holds promise for the development of new medications.

InChI:InChI=1/C7H13N3/c8-2-1-5-10-6-3-9-4-7-10/h9H,1,3-7H2

Upstream product

• 110-85-0 piperazine 
• 107-13-1 acrylonitrile 

Downstream Products

• 1415986-50-3 3-[4-({2-[4-(trifluoromethyl)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl}sulfonyl)piperazin-1-yl]propanenitrile 
• 1258411-08-3 C₂₂H₂₄ClN₉OS 
• 713145-08-5 3-{6-[4-(2-cyano-ethyl)-piperazin-1-yl]-[1,7]naphthyridin-8-yl}-benzonitrile 
• 916140-66-4 3-[4-(3-diphenylaminopropyl)piperazin-1-yl]propylamine 
• 916140-59-5 3-[4-(3-diphenylaminopropyl)piperazin-1-yl]propionitrile 

Relevant articles and documents

Thioamides from 5-arylfurfural and monosubstituted piperazine derivatives (Wilgerodt-Kindler reaction)

Interaction of 5-arylfurfurals or arylaldehydes with secondary amines (monosubstituted piperazines, morpholine, piperidine) and sulfur under conditions of Wilgerodt-Kindler reaction provided N-substituted thioamides of 5-arylfuran-2-carboxylic and benzoic acids.

Aqueous aza-michael reaction of conjugated alkenes: Toward spermine

An aqueous aza-Michael reaction is efficiently achieved with excellent conversions without any additives. The method works very well on a molar scale with selectively for aliphatic amines. An intermediate for spermine is also made by this green process.

Synthesis, characterization and in vitro biological studies of novel cyano derivatives of N-alkyl and N-aryl piperazine

Cyano derivatives of N-alkyl and N-aryl piperazine have been synthesized and screened for antibacterial and antifungal activities. All the synthesized compounds showed the antibacterial activity against pathogenic strains of Staphylococcus aureus (MTCCB 737), Pseudomonas aeruginosa (MTCCB 741), Streptomyces epidermidis (MTCCB 1824) and Escherichia coli (MTCCB 1652) and antifungal activity against pathogenic strains of Aspergillus fumigatus (ITCC 4517), Aspergillus flavus (ITCC 5192) and Aspergillus niger (ITCC 5405). All compounds showed mild to moderate antimicrobial activity. However, compounds 3c, 4a and 6 showed potent antibacterial activity against pathogenic strains used in the study. Compounds 3a, 3b, 4b, and 4d showed mild to moderate antifungal activity against Aspergillus pathogenic strains. The compounds reported in this study were assessed for there cytotoxicity using MTT colorimetric assay on Hela cells. All the compounds showed cell viability more than the control drug gentamicin, with compound 2 having highest i.e. 95% cell viability.