340683-01-4Relevant academic research and scientific papers
Synthesis of 1,3,4-thiadiazole, 1,2,4-triazole and 1,3,4-oxadiazole derivatives containing 1-(p-chlorophenyl)-5-methyl-1,2,3-triazol-4-yl moiety
Sun,Hui,Chu,Zhang
, p. 15 - 19 (2007/10/03)
2-Aroylamino-5-[1-(p-chlorophenyl)-5-methyl-1,2,3-triazol-4-yl] -1,3,4-thiadiazoles 3a-e and 3-[1-(p-chlorophenyl)-5-methyl-1,2,3-triazol-4-yl]-1,2,4-triazole-5(4H) -thione 4 have been synthesized by the cyclization of 4-aroyl-1-[1-(pchlorophenyl)-5-methyl-1,2,3-triazole-4-carbonyl] thiosemicarbazides 2a-e with conc. H2SO4 and 2N NaOH solution, respectively. Moreover, 2-aryl-5-[1-(p-chlorophenyl)-5-methyl-1,2,3-triazol-4-yl]-1,3,4-oxadiazoles 7a-e have been obtained by the direct condensation of 1-(p-chlorophenyl)-5-methyl-1,2,3-triazole-4-carbohydrazide with aromatic acids in the presence of POCl3. All the compounds synthesized have been characterized by their elemental analyses and spectral data.
