34071-75-5Relevant academic research and scientific papers
MIL-101-SO3H metal-organic framework as a Br?nsted acid catalyst in Hantzsch reaction: An efficient and sustainable methodology for one-pot synthesis of 1,4-dihydropyridine
Devarajan, Nainamalai,Suresh, Palaniswamy
, p. 6806 - 6814 (2019)
A straightforward and efficient methodology for the one-pot multicomponent synthesis of 1,4-dihydropyridine has been developed using MIL-101-SO3H metal-organic framework as a solid Br?nsted acid. The presence of the uniformly distributed Br?nsted acidic sulfonic acid sites throughout the framework and the high stability bestow the catalyst with excellent reactivity towards the synthesis of 1,4-dihydropyridine under simple reaction conditions using renewable ethanol as the solvent. The present methodology tolerates various functional groups and allows the synthesis of 1,4-dihydropyridine derivatives in good to excellent yields through Hantzsch reaction. The developed methodology proceeds under mild conditions, avoids corrosive reagents and special reaction conditions, and is amenable to gram scale synthesis. The sustainable nature of the catalyst was proved by the easy recovery and the reusability of the catalyst, as it was reused several times without loss in activity, which was confirmed from the FTIR, PXRD and SEM analyses of the reused catalyst.
Preparation method and application of iron dithiocarbamate complex catalyst
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Paragraph 0025-0026, (2020/09/16)
The invention discloses a preparation method and application of an iron dithiocarbamate complex catalyst, the iron dithiocarbamate complex is prepared by taking ammonium ferrous sulfate and N, N-dimethyl dithiocarbamate ligand as raw materials and distilled water, ethanol and DMF as solvents through solvothermal reaction; the prepared iron complex is used as a catalyst of Hantzsch, is high in catalytic activity and can be recycled for multiple times; solvents for catalytic reaction are water and ethanol, the pollution is small, and the iron complex as a catalyst has a wide application prospectin the fields of biomedical synthesis and catalytic materials. The method has the advantages of mild reaction conditions, low cost and low equipment investment, and is suitable for batch production.
Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction
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, (2008/06/13)
The present invention relates to chemical compounds having inhibitory activity on an intermediate conductance Ca 2+ activated potassium channel (IK Ca), and the use of such compounds for the treatment or alleviation of diseases or conditions relating to immune dysfunction. Moreover, the invention relates to a method of screening a chemical compound for inhibitory activity on an intermediate conductance Ca 2+ activated potassium channel (IK Ca).
