340759-27-5

Usage

Chemical class

Piperazine derivative

Structure

Features a piperazine ring with a benzyl group and a trifluoromethoxy substituent attached to it.

Biological activity

Potential serotonin receptor antagonist

Potential applications

Treatment of neurological disorders, mood disorders, and cancer research

Use in chemistry

Building block in organic synthesis and medicinal chemistry

Research status

Further research and testing are required to fully understand its potential applications and mechanisms of action.

Upstream product

• 110-85-0 piperazine 
• 50824-05-0 4-trifluoromethoxybenzyl bromide 
• 1634-04-4 tert-butyl methyl ether 
• 1346017-78-4 N-tert-butyloxycarbonyl-N'-(4-trifluoromethoxy)benzylpiperazine 

Downstream Products

• 1346017-91-1 ⁽³⁾-3-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)propionyl chloride 
• 1312072-46-0 3-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl) propionic acid 
• 1373886-26-0 ethyl 3-(4-((4-trifluoromethoxy)benzyl)piperazin-1-yl)propionate 
• 1361968-33-3 4-chloro-2-(6-((4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)methyl)pyridin-3-yl)quinoline 
• 1345843-71-1 2-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)acetohydrazide 
• 1345843-88-0 ethyl 2-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)acetate 

Relevant academic research and scientific papers

(6,7-DIHYDRO-2-NITRO-5H-IMIDAZOL[2,1-B][1,3]OXAZIN-6YL) AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF

(6,7-Dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)amide compounds of formula (I), and their pharmaceutically acceptable salts, preparation methods and pharmaceutical compositions thereof are disclosed, wherein m and R are defined as in the descriptio

(6,7-DIHYDRO-2-NITRO-5H-IMIDAZOL[2,1-B][1,3]OXAZIN-6-YL) AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF

(6,7-Dihydro-2-nitro-5H-imidazo [2,1-b][1,3]oxazin-6-yl)amide compounds of formula (I), and their pharmaceutically acceptable salts, preparation methods and pharmaceutical compositions thereof are disclosed, wherein m and R are defined as in the descripti

PROCASPASE-ACTIVATING COMPOUNDS AND COMPOSITIONS

The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.

Synthesis and preliminary pharmacological evaluation of 4′-arylmethyl analogues of clozapine. I - The effect of aromatic substituents

As part of a research program to develop compounds with mixed dopamine D4 and serotonin 5-HT2A antagonist activity with potential for the treatment of schizophrenia, we report a family of compounds based on structural modification of the atypical antipsychotic, clozapine (2). The chemical synthesis, structural characterization and pharmacological evaluation of a series 4′-arylmethyl analogues of clozapine are described. Preliminary receptor binding data are presented, examining primarily the electronic and positional effects of substituents on the introduced arylmethyl group, and secondarily the nature of the aryl ring.