340774-69-8

Basic information

• Product Name: ambuic acid
• Synonyms: ambuic acid
• CAS NO: 340774-69-8
• Molecular Formula: C19H26O6
• Molecular Weight: 350.40614
• Mol File: 340774-69-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ambuic acid(CAS DataBase Reference)
• NIST Chemistry Reference: ambuic acid(340774-69-8)
• EPA Substance Registry System: ambuic acid(340774-69-8)

Safety Data

• Hazardous Substances Data: 340774-69-8(Hazardous Substances Data)

Usage

Description

Ambuic acid is a cyclohexanone derived from Pestalotiopsis and Monochaetia species, exhibiting a range of bioactive properties such as antifungal, quorum sensing inhibitory, and antibacterial activities. It is particularly effective against P. ultimum and has the ability to inhibit the growth of various phytopathogenic fungi. Ambuic acid also interferes with the biosynthesis of cyclic peptides involved in quorum sensing, which plays a crucial role in bacterial communication and coordination of group behaviors.

Uses

Used in Agriculture:
Ambuic acid is used as a bioactive compound for the control of phytopathogenic fungi, such as P. ultimum, F. solani, H. sativum, and C. gramineum. Its antifungal properties make it a potential candidate for the development of new fungicides to protect crops from fungal infections.
Used in Pharmaceutical Industry:
Ambuic acid is used as an antibacterial agent for the treatment of skin infections, particularly those caused by methicillin-resistant S. aureus (MRSA). It has been shown to suppress abscess formation in a mouse model of skin infection when administered at a dose of 5 μg.
Used in Quorum Sensing Inhibition:
Ambuic acid is used as a quorum sensing inhibitor to interfere with the biosynthesis of cyclic peptides involved in bacterial communication. It inhibits the production of gelatinase biosynthesis-activating pheromone (GBAP) in E. faecalis, autoinducing peptide I (AIP-I) in S. aureus, and LsrD698 and LsrD826 in L. innocua. This inhibition can help in the development of new strategies to control bacterial infections by disrupting their communication systems.
Used in Research and Development:
Ambuic acid is used as a research tool for studying the mechanisms of action of various bioactive compounds, particularly those with antifungal, antibacterial, and quorum sensing inhibitory properties. Its unique structure and activity profile make it a valuable compound for exploring new therapeutic approaches and understanding the underlying biological processes.