340809-48-5Relevant academic research and scientific papers
Synthesis of 5-alkyl-4-amino-2-(trifluoromethyl)pyridines and their transformation into trifluoromethylated 1H-pyrazolo[4,3-c]pyridines
Tyvorskii, Vladimir I,Bobrov, Denis N,Kulinkovich, Oleg G,Tehrani, Kourosch Abbaspour,Kimpe, Norbert De
, p. 2051 - 2055 (2007/10/03)
5-Alkyl-4-amino-2-(trifluoromethyl)pyridines were prepared in good yields starting from the corresponding pyridinols either using condensation with tosyl isocyanate or by alkylation with 2-chloroacetamide and subsequent Smiles type rearrangement. The cyclisation of diazonium salts, generated from 5-alkyl-4-amino-2-(trifluoromethyl)pyridines, afforded trifluoromethylated 1H-pyrazolo[4,3-c]pyridines.
