340811-53-2

Basic information

• Product Name: 6-amino-3-methyl-4-(2-chlorophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
• CAS NO: 340811-53-2
• Molecular Weight: 286.721
• Mol File: 340811-53-2.mol

Chemical Properties

• CAS DataBase Reference: 6-amino-3-methyl-4-(2-chlorophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-3-methyl-4-(2-chlorophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile(340811-53-2)
• EPA Substance Registry System: 6-amino-3-methyl-4-(2-chlorophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile(340811-53-2)

Safety Data

• Hazardous Substances Data: 340811-53-2(Hazardous Substances Data)

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 108-26-9 3-methyl-2-pyrazoline-5-one 
• 109-77-3 malononitrile 
• 79785-97-0 hydrazine hydrate 
• 141-97-9 ethyl acetoacetate 
• 2698-41-1 o-chlorobenzylidene malononitrile 
• 132712-71-1 5-hydroxy-3-methylpyrazole 
• 623-48-3 ethyl iodoacetae 
• 7803-57-8 hydrazine hydrate 
• 105-45-3 acetoacetic acid methyl ester 

Relevant articles and documents

Magnetic nanoparticle supported hyperbranched polyglycerol catalysts for synthesis of 4H-benzo[b]pyran

A magnetic nanoparticle supported hyperbranched polyglycerol catalyst was prepared readily from inexpensive starting materials in aqueous medium that catalyzed the synthesis of 4H-benzo[b]pyran under solvent-free conditions at room temperature. X-ray diff

Novel biocompatible core/shell Fe3O4?NFC?Co(ii) as a new catalyst in a multicomponent reaction: An efficient and sustainable methodology and novel reusable material for one-pot synthesis of 4: H -pyran and pyranopyrazole in aqueous media

Today, due to the developing need for inexpensive catalysts, recyclable magnetic nanocatalysts immobilized on polysaccharides possess many advantages over classical heterogeneous catalysts. However, cellulose has been an appealing material in catalysis sc

Novel task-specific ionic liquid [Et2NH(CH2)2CO2H][AcO] as a robust catalyst for the efficient synthesis of some pyran-annulated scaffolds under solvent-free conditions

A novel task-specific ionic liquid, 2-carboxy-N,N-diethylethanaminium acetate denoted as [Et2NH(CH2)2CO2H][AcO], is prepared in an easy process and fully characterized by using suitable methods such as FT-IR, 1H-NMR, 13C-NMR, and TG, DTG and DTA analyses. After preparation, the promoting ability of this catalyst for one-pot multicomponent synthesis of 2-amino-4H-chromenes, dihydropyrano[3,2-c]chromenes and dihydropyrano[2,3-c]pyrazoles using in situ-developed arylidenemalononitriles through Knoevenagel reaction under solvent-free conditions is described. The sustainable procedure, short reaction times (6–36?min), effortless work-up, non-chromatographic purification, good-to-excellent product yields (79–96%), ease of recovery and reusability of the catalyst up to six reaction runs without a decrease of activity are the notable features of the present protocol.

Design and development of a new functionalized cellulose-based magnetic nanocomposite: preparation, characterization, and catalytic application in the synthesis of diverse pyrano[2,3-c]pyrazole derivatives

In this work, a facile protocol for the preparation of a new cellulose-based functionalized magnetic nanocomposite catalyst is described. The structure and morphology of the prepared nanomaterial was characterized by scanning electron microscopy, energy-d

Natural Phosphate K09 as a New Reusable Catalyst for the Synthesis of Dihydropyrano[2,3-c]Pyrazole Derivatives at Room Temperature

Abstract: In this study, we report a simple, efficient and green protocol for the synthesis of pyrano[2,3-c]pyrazole derivatives by the use of the natural phosphate K09 as a mild and efficient heterogeneous catalyst. The catalytic efficiency of K09 was compared with other heterogeneous catalysts to determine the best catalyst for said conversion. Easy recovery of the catalyst and its reusability, room temperature reaction conditions, short reaction time, excellent yields, are some of the important features of this protocol.

MIL-53(Fe) Metal–Organic Frameworks (MOFs) as an Efficient and Reusable Catalyst for the One-Pot Four-Component Synthesis of Pyrano[2,3-c]-pyrazoles

A novel and simple approach for the efficient and rapid synthesis of pyrano[2,3-c]-pyrazoleshas been accomplished via the four-component condensation reaction of malononitrile, hydrazine hydrate, ethyl acetoacetate, and substituted aldehydes using MIL-53(

Synthesis of pyranopyrazoles using nano-Fe-[phenylsalicylaldiminemethylpyranopyrazole]Cl2 as a new Schiff base complex and catalyst

By the condensation reaction of benzaldehyde with ethyl acetoacetate, malononitrile and hydrazine hydrate in the presence of FeCl2, a pyranopyrazole derivative was prepared which was then reacted with salicylaldehyde to afford nano-Fe-[phenylsalicylaldiminemethylpyranopyrazole]Cl2 (nano-[Fe-PSMP]Cl2). The prepared nano-Schiff base complex was fully characterized using Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, differential thermogravimetry, scanning electron microscopy and UV–visible spectroscopy, and was used as an efficient and catalyst for the preparation of pyranopyrazoles.

Synergetic effects of naturally sourced metal oxides in organic synthesis: a greener approach for the synthesis of pyrano[2,3-c]pyrazoles and pyrazolyl-4H-chromenes

Abstract: A clean and more economic protocol for the synthesis of pyrano[2,3-c]pyrazoles and pyrazolyl-4H-chromenes has been carried out using bael fruit ash (BFA) as a non-conventional natural catalyst in aqueous condition at ambient temperature. The catalyst was obtained from renewable resources by simple thermal treatment to dry rind of Aegle marmelos (Bael) fruit and formation of its active phase was confirmed by AAS, DSC-TGA, XRD, FT-IR, and SEM techniques. The BFA catalyst was found to be a green, highly active, easily biodegradable, and recyclable without loss of activity after the fifth run. The methodology provides an alternative platform to the conventional catalyzed process. Graphical Abstract: [Figure not available: see fulltext.].

Synthesis of pyrano[2,3-c]pyrazole derivatives using Fe3O4@SiO2@piperidinium benzene-1,3-disulfonate (Fe3O4@SiO2 nanoparticle-supported IL) as a novel, green and heterogeneous catalyst

A simple, green and efficient protocol for the one-pot four-component synthesis of pyrano[2,3-c]pyrazole derivatives produced from reaction between aryl aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate in the presence of nano magnetic piperidinium benzene-1,3-disulfonate was synthesized in water at 60 °C. The Fe3O4@SiO2 nanoparticle-supported IL was designed and synthesized. The present process offers advantages such as clean reaction, short reaction time, good to excellent yield, easy purification and easy recoverable catalyst.

CeO2/ZrO2 as green catalyst for one-pot synthesis of new pyrano[2,3-c]-pyrazoles

Ceria-doped zirconia (CeO2/ZrO2)-catalyzed synthesis of pyrano[2,3-c]-pyrazoles via four-component reaction of malononitrile, hydrazine hydrate, ethyl acetoacetate, and substituted aldehydes is described. The catalytic material CeOs