341028-37-3

Basic information

• Product Name: Alagebrium chloride
• Synonyms: 2-(4,5-dimethyl-1,3-thiazol-3-yl)-1-phenyl-ethanone chloride;4,5-dimethyl-3-(2-oxo-2-phenylethyl)thiazolium chloride;alagebrium chloride;ALT-711;Dimethyl-3-(2-oxo-2-phenyl)-chloride;(Alagebrium) (thiazolium salt);4,5-Dimethyl-3-(2-oxo-2-phenyl)-thiazoliumchloride;2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenylethanone chloride
• CAS NO: 341028-37-3
• Molecular Formula: C13H14ClNOS
• Molecular Weight: 267.77
• EINECS: 1308068-626-2
• Mol File: 341028-37-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 212 °C(dec.)
• Appearance: /
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Merck: 14,203
• CAS DataBase Reference: Alagebrium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Alagebrium chloride(341028-37-3)
• EPA Substance Registry System: Alagebrium chloride(341028-37-3)

Safety Data

• Hazardous Substances Data: 341028-37-3(Hazardous Substances Data)

Usage

Uses

Used in Cardiovascular Applications:
Alagebrium chloride is used as a therapeutic agent for the prevention and treatment of cardiovascular complications associated with aging, diabetes, and end-stage renal disease. It targets AGEs that contribute to the stiffening of blood vessels and the development of atherosclerosis, thereby potentially reducing the risk of cardiovascular events.
Used in Diabetic Multisymptom Pathology:
Alagebrium chloride is utilized as a treatment for diabetic multisymptom pathology, which includes conditions such as retinopathy, nephropathy, neuropathy, and ulcers. By breaking down AGEs, it may help alleviate the progression of these diabetic complications and improve the overall quality of life for patients.
Used in Obesity Treatment:
In the context of obesity, Alagebrium chloride is used to address obesity resulting from a diet high in both fat and AGEs that can cause renal impairment in animals. It inhibits AGE-mediated formation of reactive oxygen species (ROS), extracellular signal-regulated kinase phosphorylation, and cyclooxygenase-2 expression, which may contribute to weight management and overall health.
Used in Pharmaceutical Industry:
Alagebrium chloride is employed in the pharmaceutical industry as a potential drug candidate for the development of novel therapeutics targeting AGE-related conditions. Its ability to break down AGEs and mitigate their harmful effects makes it a promising compound for further research and drug development in various medical fields.

InChI:InChI=1/C13H14NOS.ClH/c1-10-11(2)16-9-14(10)8-13(15)12-6-4-3-5-7-12;/h3-7,9H,8H2,1-2H3;1H/q+1;/p-1