34103-49-6

Upstream product

• 72428-41-2 (5-phenyl-1,2,4-triazin-3-yl)trimethylammonium chloride 
• 72428-36-5 3-chloro-5-phenyl-1,2,4-triazine 
• 31952-61-1 5-phenyl-1,2,4-triazin-3-one 

Downstream Products

• 84437-56-9 4-Dimethylamino-2,6-diphenyl-pyrrolo[3,4-c]pyridine-1,3-dione 
• 123346-88-3 C₃₁H₂₆N₄O₄ 

Relevant academic research and scientific papers

Ring Transformations and Amination in Reactions of 3-Halogeno-5-phenyl-1,2,4-triazines with Potassium Amide in Liquid Ammonia

The reactions of 3-X-5-phenyl-1,2,4-triazines (X = fluoro, chloro, bromo, iodo) toward potassium amide/liquid ammonia were studied.Whereas the 3-fluoro compound gives only the 3-amino derivative, the 3-chloro, 3-bromo, and 3-iodo compounds yield a complex mixture containing, besides 3-amino-5-phenyl-1,2,4-triazine and 5-phenyl-1,2,4-triazine, ring transformation products, i.e., 3,5-diphenyl-1,2,4-triazine, 2,4-diphenyl-1,3,5-triazine, 6-amino-2,4-diphenyl-1,3,5-triazine, and 3-X-5-phenyl-1,2,4-triazole.Evidence is found that in the ring transformation of 3-X-5-phenyl-1,2,4-triazines into 2,4-diphenyl-1,3,5-triazines, benzamidine must be an intermediate.The mechanisms of the amination and ring transformation are extensively discussed.