34105-39-0Relevant academic research and scientific papers
Asymmetric hydrogenation of the C-C double bond of 1- and 1,2-methylated maleimides with cultured suspension cells of Marchantia polymorpha
Hegazy, Mohamed-Elamir F.,Shishido, Kozo,Hirata, Toshifumi
, p. 1859 - 1862 (2006)
Suspension cultured cells of Marchantia polymorpha have the potential to hydrogenate the C-C double bonds of 2-methyl- and 2,3-dimethylmaleimide derivatives to give enantiomerically pure (2R)-2-methyl- and (2R,3R)-2,3-dimethylsuccinimide derivatives, resp
Modification of Poly(vinyl chloride) by N -Phenyl Itaconimides for the Improvement of Its Thermal Stability
Elsharif, Asma M.,Al-Ghamdi, Azza A.,Abdel-Naby, Abir S.
, (2019)
Poly(vinyl chloride) (PVC) is modified by N-phenyl itaconimide derivatives (N-(RPh)IM) as modifying agents or graft comonomers. The resulting modified polymers or graft copolymers were characterized using FTIR and UV/Vis spectrophotometry. The thermal pro
N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases
Konstantinovi?, Jelena,Yahiaoui, Samir,Alhayek, Alaa,Haupenthal, J?rg,Sch?nauer, Esther,Andreas, Anastasia,Kany, Andreas M.,Müller, Rolf,Koehnke, Jesko,Berger, Fabian K.,Bischoff, Markus,Hartmann, Rolf W.,Brandstetter, Hans,Hirsch, Anna K. H.
supporting information, p. 8359 - 8368 (2020/09/16)
In light of the global antimicrobial-resistance crisis, there is an urgent need for novel bacterial targets and antibiotics with novel modes of action. It has been shown that Pseudomonas aeruginosa elastase (LasB) and Clostridium histolyticum (Hathewaya histolytica) collagenase (ColH) play a significant role in the infection process and thereby represent promising antivirulence targets. Here, we report novel N-Aryl-3-mercaptosuccinimide inhibitors that target both LasB and ColH, displaying potent activities in vitro and high selectivity for the bacterial over human metalloproteases. Additionally, the inhibitors demonstrate no signs of cytotoxicity against selected human cell lines and in a zebrafish embryo toxicity model. Furthermore, the most active ColH inhibitor shows a significant reduction of collagen degradation in an ex vivo pig-skin model.
A highly efficient and stereoselective cycloaddition of nitrones to N-arylitaconimides
Teterina, Polina S.,Efremova, Mariia M.,Sirotkina, Ekaterina V.,Novikov, Alexander S.,Khoroshilova, Olesya V.,Molchanov, Alexander P.
supporting information, (2019/08/26)
The 1,3-dipolar cycloaddition of keto- and aldonitrones with N-arylitaconimides proceeds regioselectively giving only 5-spiroisoxazolidines. In the case of aldonitrones the reaction proceeds with high diastereoselectivity. A range of the obtained adducts
Iterative Arylation of Itaconimides with Diazonium Salts through Electrophilic Palladium Catalysis: Divergent β-H-Elimination Pathways in Repetitive Matsuda-Heck Reactions
Riemer, Nastja,Shipman, Michael,Wessig, Pablo,Schmidt, Bernd
, p. 5732 - 5746 (2019/05/10)
N-Arylitaconimides, accessible from maleic anhydride, anilines, and paraformaldehyde, react with arene diazonium salts in Pd-catalyzed Matsuda-Heck arylation to the pharmacologically relevant E-configured 3-arylmethylidene pyrrolidine-2,5-diones (also kno
Synthesis of cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) and evaluation of their antifungal potential
Stiz, Dorimar,Corrêa, Rogério,D'Auria, Felicia D.,Simonetti, Giovanna,Cechinel-Filho, Valdir
, p. 647 - 654 (2016/10/18)
Background: This paper describes the synthesis of three different subfamilies of cyclic imides: methylphtalimides, carboxyl acid phtalimides and itaconimides. Methods: Fifteen compounds (five of each sub-family) were obtained by the reaction of appropriat
Synthesis, characterization, and computational study of potential itaconimide-based initiators for atom transfer radical polymerization
Deoghare, Chetana,Baby,Nadkarni, Vishnu S.,Behera, Raghu Nath,Chauhan, Rashmi
, p. 48163 - 48176 (2015/01/08)
Atom transfer radical polymerization (ATRP) has been a promising technique to provide polymers with well-defined composition, architecture, and functionality. In most of the ATRP processes, alkyl halides are used as an initiator. We report the synthesis o
Solid-state photochemistry of crystalline pyrazolines: Reliable generation and reactivity control of 1,3-biradicals and their potential for the green chemistry synthesis of substituted cyclopropanes
Shiraki, Saori,Vogelsberg, Cortnie S.,Garcia-Garibay, Miguel A.
, p. 1929 - 1937 (2013/01/16)
To expand on the limited number of examples that exist in the literature for the solid-state photodenitrogenation of azoalkanes, a series of crystalline 7-alkyl-2,3,7-triazabicyclo[3.3.0]oct-2-ene-6,8-diones with varying 4,4-substituents were prepared. Th
1-AKAN-2-OL SUBSTITUTED PIPERAZINE AND PIPERIDINE COMPOUNDS
-
Page/Page column 69, (2008/06/13)
Disclosed are novel substituted heterocyclic derivatives having the structure of Formula (I): The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermitt
Photoreactions of 2-(N-alkylarylamino) succinimides and related compounds
Ashraf, Syed A.,Hill, John,M'Hamedi, Ahmed,Zerizer, Hafiza
, p. 6747 - 6756 (2007/10/02)
On irradiation (254 nm), 2-(N-methylanilino)-N-phenylsuccinimide (6a) underwent homolysis of the C(2)-N bond to yield fission products N-methylaniline and N-phenylsuccinimide (12), along with the products of ortho- and para-rearrangement 2-[2-(N-methylamino)phenyl]-N-phenylsuccinimide (13) and 2-[4- (N-methylamino)phenyl]-N-phenylsuccinimide (14a) respectively. Similarly, irradiation of 2-(N-methyl- anilino)succinimide (6b) and N-benzyl-2-(N-methylanilino)succinimide (6c) gave N-methylaniline and the corresponding products of para-rearrangement. In contrast, both fission and type II cyclisation photo-products 12 and 17 respectively were formed from N-phenyl-2-(1,2,3,4-tetrahydroquinolin-1-yl)succinimide (16) and only the type II cyclisation product 1-hydroxy-2,7-diphenyl-2,7-diazabicyclo-[3.3.0]octan-3-one (21) was obtained from 2-(N-methylanilinomethyl)-N-phenylsuccinimide (20).
