3413-72-7 Usage
Description
MTIC, also known as a metabolite of Temozolomide, is a monocarboxylic acid amide derived from Dacarbazine with one of the methyl groups replaced by a hydrogen. It is the active metabolite of Dacarbazine and is also produced by the spontaneous hydrolysis of Temozolomide in the body. MTIC is an off-white solid and has significant applications in the pharmaceutical industry due to its antineoplastic properties.
Uses
Used in Pharmaceutical Industry:
MTIC is used as an antineoplastic agent for its ability to inhibit tumor growth and progression. It is particularly effective in treating various types of cancer by modulating oncological signaling pathways and demonstrating synergistic effects when combined with conventional chemotherapeutic drugs, enhancing chemo-sensitivity and efficacy in resistant cases.
Used in Drug Development:
MTIC is utilized in the development of novel drug delivery systems to overcome limitations and enhance its applications and efficacy against cancer cells. Various organic and metallic nanoparticles have been employed as carriers for MTIC delivery, aiming to improve its delivery, bioavailability, and therapeutic outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 3413-72-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,4,1 and 3 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3413-72:
(6*3)+(5*4)+(4*1)+(3*3)+(2*7)+(1*2)=67
67 % 10 = 7
So 3413-72-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H8N6O/c1-7-11-10-5-3(4(6)12)8-2-9-5/h2,7,11H,1H3,(H2,6,12)/b10-5+
3413-72-7Relevant articles and documents
Antitumour Imidazotetrazines. Part 12. Reactions of Mitozolomide and its 3-Alkyl Congeners with Oxygen, Nitrogen, Halogen, and Carbon Nucleophiles
Baig, Ghouse Unissa,Stevens, Malcolm F. G.
, p. 665 - 670 (2007/10/02)
Mitozolomide (1) and its 3-alkyl congeners ring-open in aqueous sodium carbonate to form 5-(3-alkyltriazen-1-yl)imidazole-4-carboxamides.The 3-methyl and 3-ethyl analogues of mitozolomide decompose in alcohols to form 2-azahypoxanthine and 5-amino-1-alkoxycarbonylimidazole-4-carboxamides.In hydrazine hydrate mitozolomide yields, principally, 5-azidoimidazole-4-carboxamide, whereas the 3-alkyl-derivatives form 5-amino-4-carbamoylimidazole-1-carbohydrazide. 5-Diazoimidazole-4-carboxamide, generated by thermolysis of mitozolomide in acetic acid or pyridine, can be trapped by reactive methylenic ketones, nitriles or esters to afford imidazotriazines.