341487-52-3Relevant academic research and scientific papers
Construction of Dihydropyrido[2,3- d]pyrimidine Scaffolds via Aza-Claisen Rearrangement Catalyzed by N-Heterocyclic Carbenes
Dzieszkowski, Krzysztof,Barańska, Izabela,Rafiński, Zbigniew
, p. 6645 - 6662 (2020)
N-Heterocyclic carbenes (NHCs) catalyzing aza-Claisen rearrangement of α,β-unsaturated enals with cyclic vinylogous amides under oxidative conditions generating potentially biologically active dihydropyridinone-fused uracils have been developed. This strategy represents a unique NHC-activation-based path with the use of 6-aminouracils as stable α,β-diEWG cyclic vinylogous amides for the efficient synthesis of bicyclic N-unprotected lactams similar to those in many useful drugs.
Efficient synthesis of N-3-substituted 6-aminouracil derivatives, via N6-[(dimethylamino)methylene] protection
Priego,Camarasa,Pe?rez-Pe?rez
, p. 478 - 482 (2007/10/03)
A convenient synthetic procedure has been developed to introduce different functional groups at position 3 of 6-amino-1-benzyl- or 6-amino-1-methyluracil based on N6-[(dimethylamino) methylene] protection. This method allows for the smooth substitution at N-3 even when base-labile or heat sensitive halide reagents are employed.
