341556-86-3Relevant academic research and scientific papers
Unprecedented Solvent-Dependent Sensitivities in Highly Efficient Detection of Metal Ions and Nitroaromatic Compounds by a Fluorescent Barium Metal-Organic Framework
Wang, Rongming,Liu, Xiaobin,Huang, Ao,Wang, Wen,Xiao, Zhenyu,Zhang, Liangliang,Dai, Fangna,Sun, Daofeng
, p. 1782 - 1787 (2016)
The assembly of a fluorescent dicarboxylate ligand with a barium ion resulted in the formation of a 3D metal-organic framework, Ba5(ADDA)5(EtOH)2(H2O)3·5DMF (UPC-17), based on a 1D rod-shaped secondary building unit. The unprecedented solvent-dependent sensitivities of UPC-17 for the detection of Fe3+/Al3+ ions and 4-nitrophenol with high efficiency were observed for the first time. Significantly, UPC-17 exhibits superior "turn-off" detection for the Fe3+ ion in methanol and acetone emulsions but shows "turn-on" detection in tetrahydrofuran emulsion. Furthermore, the visible color changes in the detection process make them easy to distinguish by the naked eye, which further increases its application potential.
Novel seco cyclopropa[c]pyrrolo[3,2-e]indole bisalkylators bearing a 3,3′-arylenebisacryloyl group as a linker
Fukuda,Seto,Furuta,Ebisu,Oomori,Terashima
, p. 1396 - 1406 (2007/10/03)
We synthesized the novel seco cyclopropa[c]pyrrolo[3,2-e]indole (CPI) bisalkylators and evaluated their antitumor activity. Among these derivatives, 11a (AT-760), in which the two seco 3-methoxycarbonyl-2-trifluoromethyl CPI (MCTFCPI) moieties are connected with a 3,3′-(1,4-phenylene)bisacryloyl group, was found to exhibit more potent cytotoxicity and antitumor activity against HeLaS3 human uterine cervix carcinoma cells and Colon 26 adenocarcinoma cells, respectively, than 8 (bizelesin, U-77,779). It also appeared that compound 11a exhibits improved in vivo efficacy in the human colon CX-1 model when compared to either compound 8 or mitomycin C (MMC). Efficacious doses for 11a were found to be 2-fold lower than those for 8.
Acrylamide derivatives and process for production thereof
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, (2008/06/13)
Acrylamide derivatives represented by General Formula (1) below: STR1 (One specific example of General Formula (1) is methyl (S,S)-3,3'-?3,3'-(1,4-phenylenediacryloyl)!-bis?1-chloromethyl-5-hydroxy-7-triflouromethyl-1, 2,3,6-tetrahydropyrrolo?3,2-e!indole-8-carboxylate.) The acrylamide derivatives represented by General Formula (1) is highly selective to cancer cells, less toxic, and highly active also against solid tumor.
