34162-79-3

Basic information

• Product Name: (1-phosphonoethenyl)phosphonic acid
• Synonyms: (1-phosphonoethenyl)phosphonic acid
• CAS NO: 34162-79-3
• Molecular Formula: C₂H₆O₆P₂
• Molecular Weight: 188.012962
• Mol File: 34162-79-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1-phosphonoethenyl)phosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1-phosphonoethenyl)phosphonic acid(34162-79-3)
• EPA Substance Registry System: (1-phosphonoethenyl)phosphonic acid(34162-79-3)

Safety Data

• Hazardous Substances Data: 34162-79-3(Hazardous Substances Data)

Upstream product

• 2666-14-0 ethane-1-hydroxy-1,1-diphosphonic acid tetrasodium salt 
• 37465-31-9 1,1-bis(diethylphosphono)ethylene 

Downstream Products

• 67293-68-9 tetramethyl ethenylidene-1,1-bis(phosphonate) 
• 87774-70-7 (2-Benzylsulfanyl-1-phosphono-ethyl)-phosphonic acid 
• 87774-69-4 (1-Phosphono-2-p-tolylsulfanyl-ethyl)-phosphonic acid 
• 960593-08-2 C₁₄H₂₄O₆P₂S 
• 960593-10-6 C₁₂H₂₀O₆P₂S 
• 960593-09-3 C₁₃H₂₂O₆P₂S 

Relevant articles and documents

Oxiranylidene-2,2-bis(phosphonate): Unambiguous Synthesis, Hydrolysis to 1,2-Dihydroxyethylidene-1,1-bis(phosphonate), and Identification as the Primary Product from Mild Na2WO4/H2O2 Oxidation of Ethylidene-1,1-bis(phosphonate)

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Challenging synthesis of bisphosphonate derivatives with reduced steric hindrance

An alternative approach is reported for the synthesis of methyl ester protected bisphosphonate building blocks, such as methylene bisphosphonate, vinylidenebisphosphonate and aryl substituted prochiral vinylidenebisphosphonates, that cannot be obtained directly from dimethyl phosphite and dichloromethane.

Bisphosphonate-Prodrugs

The present invention relates to a prodrug, comprising a pharmaceutically and/or diagnostically active compound, and one or more bisphosphonate groups, to a process for producing such a prodrug, and to a pharmaceutical composition comprising said prodrug, to be used for the treatment of bone-related disorders such as bone cancer.