34164-50-6

Upstream product

• 123245-94-3 (cyclobutylmethyl)magnesium bromide 
• 7439-95-4 magnesium 
• 1119-51-3 bromopentene 

Downstream Products

• 83688-89-5 6-(4-Pentenyl)-2,3,4,5-tetrahydropyridine 
• 16133-73-6 1-(pent-4-enyl)cyclohexanol 
• 3710-30-3 1,7-Octadiene 
• 64435-42-3 3,3,5-Trimethyl-5-(pent-4-enyl)-cyclohexan-1-on 
• 64435-43-4 4,4-dimethyl-non-8-en-2-one 
• 64435-44-5 3-Methyl-3-(4-pentenyl)cyclohexan-1-one 
• 38334-98-4 6-bromo-1-heptene 
• 5009-32-5 non-8-en-2-one 
• 92362-23-7 1-hydroxydec-9-en-5-one 
• 92362-22-6 5-pent-4-enyldec-9-ene-1,5-diol 
• 221092-87-1 3-(4-pentenyl)-1-trimethylsiloxy-1-cyclohexene 
• 82757-00-4 ((3S,4R)-3,4-Dimethyl-3-pent-4-enyl-cyclohex-1-enyloxy)-trimethyl-silane 
• 21964-51-2 hexadeca-1,15-diene 
• 89789-98-0 6-(2-methoxyphenyl)-1-hexene 

Relevant academic research and scientific papers

Synthesis of functionalized polycarbosilanes via one-pot ADMET polymerization-macromolecular substitution

Three substituted unsaturated polycarbosilanes were prepared from the same parent using a two-step, one-pot ADMET polycondensation-nucleophilic substitution route. Condensation metathesis of di(4-pentenyl)dichlorosilane using Schrock's [Mo] catalyst produces a polymer backbone containing two reactive silicon-chlorine bonds per unit. Replacement of these bonds with stable alkyl moieties was performed using an excess of alkyllithium reagent without undesirable main chain alkylation or cross-linking. Upon functionalization, moisture-stable polymers were synthesized, indicating quantitative substitution was achieved. All of the resulting polymers are amorphous, elastomeric materials. Variation of the two pendant groups from phenyl to methyl resulted in a Tg change of over 85°C.

The preparation of HfC/C ceramics via molecular design

Polymer derived ceramics have received lots of attention throughout the last few decades. Unfortunately, only a few precursor systems have been developed, focusing on silicon based polymers and ceramics, respectively. Herein, the synthesis of novel hafniu

PIKFYVE KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) as well as their use for treating diseases and disorders associated with PIKfyve.

Synthesis of 1-azaspiro[4.4]nonan-1-oxyls via intramolecular 1,3-dipolar cycloaddition

Sterically shielded nitroxides of the pyrrolidine series have shown the highest resistance to reduction. Here we report the synthesis of new pyrrolidine nitroxides from 5,5-dialkyl-1-pyrroline N-oxides via the introduction of a pent-4-enyl group to the nitrone carbon followed by an intramolecular 1,3-dipolar cycloaddition reaction and isoxazolidine ring opening. The kinetics of reduction of the new nitroxides with ascorbate were studied and compared to those of previously published (1S,2R,3′S,4′S,5′S,2″R)-dispiro[(2-hydroxymethyl)cyclopentan-1,2′-(3′,4′-di-tert-butoxy)pyrrolidine-5′,1″-(2″-hydroxymethyl)cyclopentane]-1′-oxyl (1).

Controllable, Sequential, and Stereoselective C-H Allylic Alkylation of Alkenes

The direct conversion of C-H bonds into new C-C bonds represents a powerful approach to generate complex molecules from simple starting materials. However, a general and controllable method for the sequential conversion of a methyl group into a fully substituted carbon center remains a challenge. We report a new method for the selective and sequential replacement of three C-H bonds at the allylic position of propylene and other simple terminal alkenes with different carbon groups derived from Grignard reagents. A copper catalyst and electron-rich biaryl phosphine ligand facilitate the formation of allylic alkylation products in high branch selectivity. We also present conditions for the generation of enantioenriched allylic alkylation products in the presence of catalytic copper and a chiral phosphine ligand. With this approach, diverse and complex products with substituted carbon centers can be generated from simple and abundant feedstock chemicals.

A Short Access to Symmetrically α,α-Disubstituted α-Amino Acids from Acyl Cyanohydrins

A straightforward synthesis of symmetrically α,α-disubstituted α-amino acids is presented. The key step of this process relies on the efficient double addition of Grignard reagents to acyl cyanohydrins to provide N-acyl amino alcohols selectively in good yields. The chemoselectivity of the reaction was modulated by the nature of the acyl moiety. Eleven amino acids were prepared, including the particularly simple divinylglycine, which is not easily accessible by using conventional methods.

MACROCYCLIC AND BICYCLIC INHIBITORS OF HEPATITIS C VIRUS

Compounds of formula (I):or pharmaceutically acceptable salts thereof, wherein the various substituents are defined herein, methods of using said compounds, and pharmaceutical compositions containing said compounds.

Synthesis of a platform to access bistramides and their analogues

The platform C14-C40, which can be used to prepare bistramide C and 39-oxobistramide K, was synthesized in 19 steps with an overall yield of 6.2%. Furthermore, the chemoselective reduction of the ketone at C-39 was performed giving an easy access to bistramides A, B, D, K, and L. Finally, the versatility of the synthesis of the C14-C40 fragment can allow the preparation of a large variety of stereoisomers to produce bistramide analogues.

l , l , 3-TRI0X0-l , 2 , 5-THIADIAZ0LIDINES AND THEIR USE AS PTP-ASES INHIBITORS

Compounds of the formula are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the present invention may also be employed as inhibitors of other e

6R-(3,6-DIDEOXY-L-ARABINO-HEXOPYRANOSYLOXY)HEPTANOIC ACID, PREPARATION PROCESS FOR THE SAME AND DAUER EFFECT THEREOF

The present invention relates to a determination of a stereochemistry, a synthesis and dauer effect of 6R-(3,6-dideoxy-L-arabino-hexopyranosyloxy) heptanoic acid as a pheromone isolated from the Caenorhabditis elegance related to suppress of aging and