3418-24-4

Basic information

• Product Name: 2-(BROMOMETHYL)-2-(4-CHLOROPHENYL)-1,3-DIOXOLANE
• Synonyms: BUTTPARK 147\06-68;2-(BROMOMETHYL)-2-(4-CHLOROPHENYL)-1,3-DIOXOLANE;2-(BROMOMETHYL)-2-(P-CHLOROPHENYL)DIOXOLANE
• CAS NO: 3418-24-4
• Molecular Formula: C₁₀H₁₀BrClO₂
• Molecular Weight: 277.54
• Mol File: 3418-24-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 335°Cat760mmHg
• Flash Point: 156.4°C
• Appearance: /
• Density: 1.545g/cm³
• Vapor Pressure: 0.000239mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 2-(BROMOMETHYL)-2-(4-CHLOROPHENYL)-1,3-DIOXOLANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BROMOMETHYL)-2-(4-CHLOROPHENYL)-1,3-DIOXOLANE(3418-24-4)
• EPA Substance Registry System: 2-(BROMOMETHYL)-2-(4-CHLOROPHENYL)-1,3-DIOXOLANE(3418-24-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 3418-24-4(Hazardous Substances Data)

Usage

General Description

2-(Bromomethyl)-2-(4-chlorophenyl)-1,3-dioxolane is a chemical compound that belongs to the group of dioxolanes, which are cyclic organic compounds containing two oxygen atoms in a five-membered ring. This specific compound contains a bromomethyl group and a 4-chlorophenyl group attached to the dioxolane ring. It is commonly used in organic synthesis as a reagent for various chemical reactions, including in the production of pharmaceuticals and agrochemicals. Its unique structure and reactivity make it a valuable building block in the synthesis of complex organic molecules. However, it is important to handle this compound with care due to its potential health hazards and environmental impact.

InChI:InChI=1/C10H10BrClO2/c11-7-10(13-5-6-14-10)8-1-3-9(12)4-2-8/h1-4H,5-7H2

Upstream product

• 107-21-1 ethylene glycol 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 1353585-94-0 1-{[2-(4-chlorophenyl)-1,3-dioxolan-2-yl]methyl}-1H-imidazole hydrochloride 
• 1267484-28-5 8-chloro-5-((2-(4-chlorophenyl)-1,3-dioxolan-2-yl)methyl)-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 711017-59-3 S-{[2-(4-chlorophenyl)-1,3-dioxolan-2-yl]methyl}ethanethioate 
• 60207-61-6 1-((2-(4-chlorophenyl)-1,3-dioxolane-2-yl)methyl)-1H-1,2,4-triazole 

Relevant articles and documents

Propiconazole-like compound, and preparation method and application thereof

The invention discloses a propiconazole-like compound, and a preparation method and application thereof. The structural formula of the propiconazole-like compound is represented by formula (I)shown in the specification. In the formula (I), X is H, bromine

One-step for the preparation of α-haloacetal of ketones with N-bromosuccinimide/N-chlorosuccinimide (NBS/NCS) and ethylene glycol

A new process that could directly prepare α-haloacetal of ketones from various ketones with N-halosuccinimide (NBS/NCS) and ethylene glycol in one step without any other catalysts was reported. The effects of solvents, NBS/NCS and reaction temperature were investigated. Under the optimal condition, most of α-haloacetals of ketones were obtained in 90–100% yield.

A specific and potent inhibitor of brassinosteroid biosynthesis possessing a dioxolane ring.

Screening for brassinosteroid biosynthesis inhibitors was performed to find azole derivatives that induced dwarfism, to resemble brassinosteroid-deficient mutants in Arabidopsis, and which could be rescued by brassinosteroid. Through this screening experiment, propiconazole fungicide was selected as a likely inhibitor of brassinosteroid biosynthesis and, thus, propiconazole derivatives with optimized activity and selectivity were synthesized. The biological activity of these compounds was evaluated by examining cress stem elongation. Among the compounds tested, 2RS,4RS-1-[2-(4-trifluoromethylphenyl)-4-n-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole (12) showed the most potent capability to retard cress stem elongation in the light. The compound-induced hypocotyl dwarfism was restored by the coapplication of 10 nM brassinolide but not by 1 microM gibberellin. These results suggest that 12 should affect brassinosteroid biosynthesis. The potency and specificity of 12 were greater than those of brassinazole, a previously reported brassinosteroid biosynthesis inhibitor.