3418-28-8

Basic information

• Product Name: 2-(BROMOMETHYL)-2-(4-NITROPHENYL)-1,3-DIOXOLANE
• Synonyms: 2-(BROMOMETHYL)-2-(P-NITROPHENYL)DIOXOLANE;2-(BROMOMETHYL)-2-(4-NITROPHENYL)-1,3-DIOXOLANE
• CAS NO: 3418-28-8
• Molecular Formula: C₁₀H₁₀BrNO₄
• Molecular Weight: 288.09
• Mol File: 3418-28-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 130-133 °C
• Boiling Point: 393.2°Cat760mmHg
• Flash Point: 191.6°C
• Appearance: /
• Density: 1.604g/cm³
• Vapor Pressure: 4.9E-06mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: 2-(BROMOMETHYL)-2-(4-NITROPHENYL)-1,3-DIOXOLANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BROMOMETHYL)-2-(4-NITROPHENYL)-1,3-DIOXOLANE(3418-28-8)
• EPA Substance Registry System: 2-(BROMOMETHYL)-2-(4-NITROPHENYL)-1,3-DIOXOLANE(3418-28-8)

Safety Data

• Hazardous Substances Data: 3418-28-8(Hazardous Substances Data)

Usage

General Description

2-(Bromomethyl)-2-(4-nitrophenyl)-1,3-dioxolane is a chemical compound with the molecular formula C9H8BrNO4. It is a dioxolane derivative that contains a bromomethyl and a 4-nitrophenyl group. 2-(BROMOMETHYL)-2-(4-NITROPHENYL)-1,3-DIOXOLANE is commonly used in organic synthesis as a reagent for the introduction of the bromomethyl group into other molecules. It is also used in the production of pharmaceuticals and agrochemicals. 2-(Bromomethyl)-2-(4-nitrophenyl)-1,3-dioxolane is a flammable and potentially toxic substance, and appropriate safety precautions should be taken when handling and storing it.

InChI:InChI=1/C10H10BrNO4/c11-7-10(15-5-6-16-10)8-1-3-9(4-2-8)12(13)14/h1-4H,5-7H2

Upstream product

• 6531-13-1 1-[4-nitrophenyl]-1-ethanol 
• 107-21-1 ethylene glycol 
• 100-19-6 (4-nitrophenyl)ethanone 

Downstream Products

• 60207-38-7 1-[2-(4-nitro-phenyl)-[1,3]dioxolan-2-ylmethyl]-1H-[1,2,4]triazole 

Relevant articles and documents

Application of poly(vinylphenyltrimethylammonium tribromide) resin as an efficient polymeric brominating agent in the α-bromination and α-bromoacetalization of acetophenones

The applications of a new supported tribromide reagent based on poly(vinylbenzyltrimethylammonium hydroxide) resin (Amberlite 717) were reported. This supported tribromide resin was used directly in α-bromination and α-bromoacetalization of acetophenones without any other catalyst under mild conditions. The effects of solvents and the amount of the supported tribromide resin on the reactions were investigated. Under the optimal conditions, most of α-bromo and α-bromoacetal of acetophenones were selectively obtained in excellent yields.

One-step for the preparation of α-haloacetal of ketones with N-bromosuccinimide/N-chlorosuccinimide (NBS/NCS) and ethylene glycol

A new process that could directly prepare α-haloacetal of ketones from various ketones with N-halosuccinimide (NBS/NCS) and ethylene glycol in one step without any other catalysts was reported. The effects of solvents, NBS/NCS and reaction temperature were investigated. Under the optimal condition, most of α-haloacetals of ketones were obtained in 90–100% yield.