3418-28-8

Usage

Uses

Used in Organic Synthesis:
2-(BROMOMETHYL)-2-(4-NITROPHENYL)-1,3-DIOXOLANE is used as a reagent for the introduction of the bromomethyl group into other molecules, which is crucial for the synthesis of various organic compounds. Its ability to facilitate the formation of new carbon-carbon bonds makes it a valuable tool in organic chemistry.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2-(BROMOMETHYL)-2-(4-NITROPHENYL)-1,3-DIOXOLANE is used as an intermediate in the synthesis of various drugs. Its unique structure allows for the creation of new pharmaceutical compounds with potential therapeutic applications.
Used in Agrochemical Production:
Similarly, in the agrochemical industry, 2-(BROMOMETHYL)-2-(4-NITROPHENYL)-1,3-DIOXOLANE is utilized as a precursor in the development of agrochemicals, such as pesticides and herbicides. Its role in these applications is to provide a functional group that can be further modified to achieve the desired biological activity.
Safety Precautions:
Given its flammable and potentially toxic properties, 2-(BROMOMETHYL)-2-(4-NITROPHENYL)-1,3-DIOXOLANE requires special attention during handling and storage. It is essential to follow safety guidelines, such as using proper personal protective equipment, storing in a well-ventilated area away from ignition sources, and disposing of it according to chemical waste regulations.

InChI:InChI=1/C10H10BrNO4/c11-7-10(15-5-6-16-10)8-1-3-9(4-2-8)12(13)14/h1-4H,5-7H2

Upstream product

• 107-21-1 ethylene glycol 
• 100-19-6 (4-nitrophenyl)ethanone 
• 6531-13-1 1-[4-nitrophenyl]-1-ethanol 

Downstream Products

• 60207-38-7 1-[2-(4-nitro-phenyl)-[1,3]dioxolan-2-ylmethyl]-1H-[1,2,4]triazole 

Relevant academic research and scientific papers

Application of poly(vinylphenyltrimethylammonium tribromide) resin as an efficient polymeric brominating agent in the α-bromination and α-bromoacetalization of acetophenones

The applications of a new supported tribromide reagent based on poly(vinylbenzyltrimethylammonium hydroxide) resin (Amberlite 717) were reported. This supported tribromide resin was used directly in α-bromination and α-bromoacetalization of acetophenones without any other catalyst under mild conditions. The effects of solvents and the amount of the supported tribromide resin on the reactions were investigated. Under the optimal conditions, most of α-bromo and α-bromoacetal of acetophenones were selectively obtained in excellent yields.

One-pot synthesis of α-bromoacetals of ketones from secondary alcohols and 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) in ethylene glycol

α-Bromoacetals of ketones were prepared from various secondary alcohols with 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) and ethylene glycol through oxidation, bromination, and acetalization in one pot without the use of other catalysts under mild conditions. The effects of DBDMH, the solvent, and N-bromosuccinimide on the reaction were investigated. Under the optimal conditions, most α-bromoacetals of ketones were obtain in 90–98% yields.

One-step for the preparation of α-haloacetal of ketones with N-bromosuccinimide/N-chlorosuccinimide (NBS/NCS) and ethylene glycol

A new process that could directly prepare α-haloacetal of ketones from various ketones with N-halosuccinimide (NBS/NCS) and ethylene glycol in one step without any other catalysts was reported. The effects of solvents, NBS/NCS and reaction temperature were investigated. Under the optimal condition, most of α-haloacetals of ketones were obtained in 90–100% yield.