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BLOOM TECH Advanced API/Technology support PROPAFENONE HYDROCHLORIDE CAS 34183-22-7
Cas No: 34183-22-7
USD $ 5.0-5.0 / Gram 1 Gram 500 Kilogram/Month Shaanxi BLOOM TECH Co.,Ltd Contact Supplier
Propafenone hydrochloride Manufacturer/High quality/Best price/In stock
Cas No: 34183-22-7
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality Propafenone Hcl supplier in China
Cas No: 34183-22-7
No Data No Data Metric Ton/Day Simagchem Corporation Contact Supplier
CAS:366-70-1 Procarbazine hydrochloride
Cas No: 34183-22-7
No Data 1 Kilogram 100 Kilogram/Week Kono Chem Co.,Ltd Contact Supplier
propafenone hcl CAS 34183-22-7 manufacturer/supplier
Cas No: 34183-22-7
No Data 1 Gram 100 Kilogram/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
USP standard Propafenone hydrochloride CAS 34183-22-7 supplied by manufacturer
Cas No: 34183-22-7
USD $ 900.0-1100.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
High Quality 99% Propafenone Hcl 34183-22-7 GMP manufacturer
Cas No: 34183-22-7
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Factory Supply Propafenone Hcl
Cas No: 34183-22-7
No Data 1 1 Ality Chemical Corporation Contact Supplier
Antiarrhythmic Drug CAS 34183-22-7 Propafenone Hydrochloride
Cas No: 34183-22-7
USD $ 380.0-380.0 / Kilogram 1 Kilogram 5000 Kilogram/Quarter Xi'an Harmonious Natural Bio-Technology Co., Ltd. Contact Supplier
High Purity Pharmaceutical Raw Material Propafenone Hydrochloride
Cas No: 34183-22-7
USD $ 50.0-110.0 / Kilogram 1 Kilogram 5000 Kilogram/Month Xi'an Julong Bio-Tech Co., Ltd. Contact Supplier

34183-22-7 Usage

Uses

Antiarrhythmic;'Beta adrenergic antagonist

Uses

A sodium channel protein inhibitor.

Brand name

Rythmol (Reliant).

Uses

Sodium channel blocker. Antiarrhythmic (class IC)

Chemical Properties

White Solid

Definition

ChEBI: A hydrochloride that is the monohydrochloride salt of propafenone. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used in the management of supraventricular and ventricular arrhythmias.
InChI:InChI=1/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H

34183-22-7 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (P2301)  Propafenone Hydrochloride  >98.0%(HPLC)(T) 34183-22-7 1g 690.00CNY Detail
Sigma-Aldrich (Y0000455)  Propafenone hydrochloride  European Pharmacopoeia (EP) Reference Standard 34183-22-7 Y0000455 1,880.19CNY Detail
Sigma (P4670)  Propafenone hydrochloride   34183-22-7 P4670-5G 1,193.40CNY Detail
USP (1570304)  Propafenone hydrochloride  United States Pharmacopeia (USP) Reference Standard 34183-22-7 1570304-200MG 4,662.45CNY Detail

34183-22-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name propafenone hydrochloride

1.2 Other means of identification

Product number -
Other names 1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:34183-22-7 SDS

34183-22-7Synthetic route

propylamine
107-10-8

propylamine

1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one
22525-95-7

1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

Conditions
ConditionsYield
Stage #1: propylamine; 1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one for 4h; Reflux;
Stage #2: With hydrogenchloride In water for 1h; Reflux;
85%
Stage #1: propylamine; 1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one at 20 - 50℃; for 6h;
Stage #2: With hydrogenchloride for 1h; Reflux;
74.5%
2'-hydroxydihydrochalcone sodium

2'-hydroxydihydrochalcone sodium

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 8 h / 110 °C
2.1: 6 h / 20 - 50 °C
2.2: 1 h / Reflux
View Scheme
1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one
1214-47-7

1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 2-Phenylbenzothiazolin; aluminum (III) chloride / toluene / 2 h / 110 °C
1.2: 6 h / 20 - 25 °C
2.1: 8 h / 110 °C
3.1: 6 h / 20 - 50 °C
3.2: 1 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: tris(pentafluorophenyl)borate; triethylsilane; 1,1,1,3',3',3'-hexafluoro-propanol / 1 h / 40 °C
2.1: 4 h / Reflux
3.1: 4 h / Reflux
3.2: 1 h / Reflux
View Scheme
1-(2-(allyloxy)phenyl)-3-phenylpropan-1-one

1-(2-(allyloxy)phenyl)-3-phenylpropan-1-one

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 20 °C
2.1: 4 h / Reflux
2.2: 1 h / Reflux
View Scheme
2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 4 h / Reflux
2.1: 4 h / Reflux
2.2: 1 h / Reflux
View Scheme
2'-allyloxychalcone
16619-51-5

2'-allyloxychalcone

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: tris(pentafluorophenyl)borate; triethylsilane; 1,1,1,3',3',3'-hexafluoro-propanol / 1 h / 40 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 20 °C
3.1: 4 h / Reflux
3.2: 1 h / Reflux
View Scheme
propafenone hydrochloride
34183-22-7

propafenone hydrochloride

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

C27H41NO3Si

C27H41NO3Si

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane at 0 - 22℃; for 12h; Inert atmosphere;83%
propafenone hydrochloride
34183-22-7

propafenone hydrochloride

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

C22H25NO4

C22H25NO4

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 50℃; for 12h;68%
copper(II) choride dihydrate

copper(II) choride dihydrate

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

[(1-[2-[2-oxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone(1-))2 (copper(II))2 (chloride)2]
907997-08-4

[(1-[2-[2-oxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone(1-))2 (copper(II))2 (chloride)2]

Conditions
ConditionsYield
With NaOH In methanol at room temp., methanolic soln. of hydrochloride of the ligand mixed with soln. of CuCl2*2H2O in the same solvent (ratio 1:1), dropwise additionof NaOH; pptn., crystals filtered, washed with methanol, dried over P2O5; elem. anal.;60%
propafenone hydrochloride
34183-22-7

propafenone hydrochloride

C21H25(2)H2NO3

C21H25(2)H2NO3

Conditions
ConditionsYield
With 2,2,6,6-tetramethyl-piperidine; tris(pentafluorophenyl)borate; water-d2 In tetrahydrofuran at 100℃; for 12h; Inert atmosphere; regioselective reaction;46%
copper(II) choride dihydrate

copper(II) choride dihydrate

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

trans-N-[(1-[2-[2-oxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone(1-))2 copper(II)]
907997-07-3

trans-N-[(1-[2-[2-oxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone(1-))2 copper(II)]

Conditions
ConditionsYield
With NaOH In methanol at room temp. CuCl2*2H2O in MeOH added to the hydrochloride of the ligand in the same solvent (ratio 1:10), dropwise addition of NaOH; pptn. of crystals after 5 d, crystals filtered, washed with methanol, recrystallized from ethanol, dried over P2O5; elem. anal.;35%
propafenone hydrochloride
34183-22-7

propafenone hydrochloride

uridine 5'-diphosphoglucuronic acid triammonium salt

uridine 5'-diphosphoglucuronic acid triammonium salt

Propafenone glucuronide

Propafenone glucuronide

Conditions
ConditionsYield
With mercaptoethyl alcohol; sepharose bound UDP-glucuronyltransferase; magnesium chloride In ethanol at 37℃; for 4h; Product distribution; Tris-HCl buffer; pH and concentrations varied; enzyme activity;
With mercaptoethyl alcohol; magnesium chloride In ethanol at 37℃; for 4h; Sepharose bound UDP-glucuronyltransferase, Tris-HCl buffer pH 7.5; Yield given;
propafenone hydrochloride
34183-22-7

propafenone hydrochloride

C40H51NO3Si

C40H51NO3Si

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 0 - 22 °C / Inert atmosphere
2: triethylamine / acetonitrile / 12 h / 0 - 22 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: 1H-imidazole / dichloromethane / 12 h / 0 - 22 °C / Inert atmosphere
2: triethylamine / acetonitrile / 12 h / 0 - 22 °C / Inert atmosphere
View Scheme
propafenone hydrochloride
34183-22-7

propafenone hydrochloride

C40H47(2)H4NO3Si

C40H47(2)H4NO3Si

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 0 - 22 °C / Inert atmosphere
2: triethylamine / acetonitrile / 12 h / 0 - 22 °C / Inert atmosphere
3: [(2)H6]acetone; tris(pentafluorophenyl)borate / toluene / 3 h / 150 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: 1H-imidazole / dichloromethane / 12 h / 0 - 22 °C / Inert atmosphere
2: triethylamine / acetonitrile / 12 h / 0 - 22 °C / Inert atmosphere
3: [(2)H6]acetone; tris(pentafluorophenyl)borate / toluene / 3 h / 150 °C / Inert atmosphere
View Scheme
t-butyldimethylsiyl triflate
69739-34-0

t-butyldimethylsiyl triflate

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

C27H41NO3Si

C27H41NO3Si

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 22℃; Inert atmosphere;

34183-22-7Upstream product

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