341998-54-7

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 341998-53-6 1-[1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]ethanone 
• 98-59-9 p-toluenesulfonyl chloride 
• 83393-46-8 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethan-1-one 
• 271-63-6 7-Azaindole 

Downstream Products

• 950916-51-5 1-(2-methoxyethyl)-3-(2-phenylaminopyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridine 
• 341998-55-8 Meriolin 1 

Relevant academic research and scientific papers

Synthesis of the indole alkaloids meridianins from the tunicate Aplidium meridianum

The marine natural products meridianins A and C-E have been synthesized for the first time starting from the appropriate N-tosyl-3-acetylindole. A facile two-step conversion of N-tosyl-3-acetylindoles to the corresponding meridianins by treatment with dimethylformamide dimethylacetal and further cyclization of the resulting enaminone with aminoguanidine is described. This method has also been applied for the preparation of the 3-[(2-amino)pyrimidin-4-yl]-7-azaindole.

4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES

Compounds of the formula I in which R1, R2, R3, R4 and R5 are each as defined in claim 1 are inhibitors of cell proliferation/cell vitality and can be used to treat tumors.