34218-84-3

Usage

Uses

Used in Pharmaceutical Industry:
2'-(O-METHYL)-5-IODOURIDINE is used as a chemotherapeutic agent for the induction of neuronal differentiation. It plays a crucial role in the treatment of various neurological disorders and cancer types, particularly those involving the central nervous system. 2'-(O-METHYL)-5-IODOURIDINE's ability to promote neuronal differentiation makes it a valuable tool in the development of targeted therapies for cancer and other related conditions.
Used in Research and Development:
In addition to its therapeutic applications, 2'-(O-METHYL)-5-IODOURIDINE is also utilized in research and development for the study of cellular processes and mechanisms underlying neuronal differentiation. It serves as a valuable tool for understanding the molecular pathways involved in the development and maintenance of the nervous system, as well as the factors that contribute to the onset and progression of neurological disorders.
Used in Drug Delivery Systems:
Similar to gallotannin, 2'-(O-METHYL)-5-IODOURIDINE can also be incorporated into novel drug delivery systems to enhance its applications and efficacy against specific conditions. Various organic and metallic nanoparticles can be employed as carriers for the delivery of 2'-(O-METHYL)-5-IODOURIDINE, aiming to improve its delivery, bioavailability, and therapeutic outcomes in targeted treatments.

Upstream product

• 2140-76-3 2'-O-methyluridine 

Downstream Products

• 220090-10-8 Acetic acid 2-acetoxy-1-(1-{(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-methoxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-ethyl ester 

Relevant academic research and scientific papers

A semi-rigid isoindoline-derived nitroxide spin label for RNA

A new isoindoline-derived benzimidazole nitroxide spin label, ImUm, was synthesized and incorporated into RNA oligoribonucleotides. ImUm is the first example of a conformationally unambiguous spin label for RNA, in which the nitroxide N-O bond lies on the same axis as the single bond used to attach the rigid isoindoline-based spin label to a uridine base. This results in minimal displacement of the nitroxide upon rotation of this single bond, which is a useful property for a label to be used for distance measurements. Continuous-wave (CW) EPR measurements of RNA duplexes containing ImUm indicate a restricted rotation around this single bond, presumably due to an intramolecular hydrogen bond between the benzimidazole N-H and O4 of the uracil. Orientation-selective pulsed electron-electron double resonance (PELDOR, also called double electron-electron resonance, or DEER) distance measurements between two spin labels in two RNA duplexes showed in one case a strong orientation dependence, further confirming the restricted motion of the spin labels in RNA duplexes.

S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS

Various embodiments provide STOPS? polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS? modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS? modified oligonucleotides, as determined by HBsAg Secretion Assay, is an EC50 that is less than 100 nM.

Oligonucleotides bearing 5-formyl-2 '-O-methyluridine: Preference in binding affinity to the NF-κB (p50)2 homo- and p50/p65 heterodimers

5-Formyl-2'-O-methyluridine was incorporated into the various positions of oligonucleotide 26-mers containing the NF-κB binding sequence. Some of them showed binding selectivity toward the homo- and heterodimers of subunits of NF-κB.