34235-81-9

Basic information

• Product Name: N-(P-TOSYL)-L-ISOLEUCINE
• Synonyms: N-(P-TOSYL)-L-ISOLEUCINE
• CAS NO: 34235-81-9
• Molecular Formula: C₁₃H₁₉NO₄S
• Molecular Weight: 285.35926
• Mol File: 34235-81-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 450.1°C at 760 mmHg
• Flash Point: 226°C
• Appearance: /
• Density: 1.218g/cm³
• Vapor Pressure: 6.87E-09mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: N-(P-TOSYL)-L-ISOLEUCINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(P-TOSYL)-L-ISOLEUCINE(34235-81-9)
• EPA Substance Registry System: N-(P-TOSYL)-L-ISOLEUCINE(34235-81-9)

Safety Data

• Hazardous Substances Data: 34235-81-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H19NO4S/c1-4-10(3)12(13(15)16)14-19(17,18)11-7-5-9(2)6-8-11/h5-8,10,12,14H,4H2,1-3H3,(H,15,16)

Upstream product

• 959215-79-3 (2RS,3S)-2-amino-3-methylpentanoic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 73-32-5 DL-isoleucine 
• 73-32-5 L-isoleucine 
• 104-15-4 toluene-4-sulfonic acid 
• 319-78-8 isoleucine 

Downstream Products

• 101740-27-6 N-[N-(toluene-4-sulfonyl)-L-isoleucyl]-glycine ethyl ester 
• 26465-78-1 (2-methylbutane-1,1-diyl)dibenzene 
• 26613-38-7 1,2-diphenyl-2-methylbutane 
• 219674-34-7 crotyl N-tosyl-(S)-isoleucylglycinate 
• 72676-80-3 N-(toluene-4-sulfonyl)-L-isoleucyl chloride 
• 1303530-13-3 2-[(2-bromobenzyl)(toluene-4-sulfonyl)amino]-3-methylpentanoic acid methyl ester 
• 1303530-21-3 N-(2-bromobenzyl)-N-(1-hydroxymethyl-2-methylbutyl)-4-methylbenzenesulfonamide 
• 932725-33-2 3-sec-butyl-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine 
• 1254592-72-7 C₁₅H₂₅N₃O₄PdS*H₂O 
• 1428989-73-4 C₂₃H₂₅N₃O₄PdS 
• 72676-80-3 α-Tosylamino-β-methyl-valerylchlorid 
• 898558-08-2 (2S,3S)-N-(4-toluenesulfonyl)-2-amino-3-methyl-pentanol 

Relevant articles and documents

Isoleucine with secondary sulfonamide functionality as anticancer, antibacterial and antifungal agents

Isoleucine substituted analogues with secondary sulfonamide group (I1–I6) have been synthesized. Structures of synthesized analogues have been confirmed by Fourier Transform-Infrared Red, Nuclear Magnetic Resonance (1H and 13C) and ESI-MS spectroscopic tools. Cytotoxic screenings of synthesized analogues have been done on MCF-7 (breast), Prostate Cancer-3 (PC-3) and A549 (lung) cancer cell lines. N-(1-isobutyl-2-oxo-2-anilinoethyl) p-toluene sulfonamide (I5) screened to be better cytotoxic agent on MCF-7 and A549 cell lines whereas N-(1-isobutyl-2-oxo-2-p-chloroanilino ethyl) benzene sulfonamide (I3) against PC-3 cell line. Cell cycle analysis of N-(1-isobutyl-2-oxo-2-anilinoethyl) p-toluene sulfonamide (I5) analogue has been carried out on A549 cell line in comparison to control and Vinblastine (standard drug). Complete arrest in G0 and G1 phase along with mild disturbance in S-phase of cell cycle has been observed. The screened analogues (I1–I6) also showed good antifungal and antibacterial potential against gram positive as well as gram negative strains. Computer simulation indicated good bioactivity prediction by the ‘Lipinski rule’ and synthesized analogues did not violate this rule. Docking study of isoleucine sulfonamide analogues (I1–I6) were carried out to determine the possible interaction sites of the analogues with p53 tumor suppressor-DNA complex and demonstrate that the analogues confirmed binding and inhibition with the most mutated residues of p53. Density functional theory has been used to correlate the electronic and chemical properties of analogues and they were found to be stable and chemically reactive. Thus the results suggest that isoleucine substituted sulfonamide analogues can serve as a structural model for the design of anticancer agents, antibacterial agents as well as antifungal agents with better inhibitory potential. Communicated by Ramaswamy H. Sarma.

NMR-based assignment of isoleucine: Vs. allo -isoleucine stereochemistry

A simple 1H and 13C NMR spectrometric analysis is demonstrated that permits differentiation of isoleucine and allo-isoleucine residues by inspection of the chemical shift and coupling constants of the signals associated with the proton and carbon at the α-stereocentre. This is applied to the estimation of epimerisation during metal-free N-arylation and peptide coupling reactions.

Asymmetric hydrogenation of N-sulfonylated-α-dehydroamino acids: Toward the synthesis of an anthrax lethal factor inhibitor

(Chemical Equation Presented) A novel and highly enantioselective Ru-catalyzed hydrogenation of N-sulfonylated-α-dehydroamino acids has been discovered and demonstrated in the synthesis of an anthrax lethal factor inhibitor (LFI). Herein, this methodology is used to prepare N-sulfonylated amino acids in up to 98% ee. This unprecedented hydrogenation uses a chiral Ru catalyst rather than Rh as typical for acylated dehydroamino acids and esters, and this work reports the first asymmetric hydrogenation of a tetrasubstituted dehydroamino acid derivative using a Ru catalyst.