34245-63-1

Basic information

• Product Name: 5'-<(aminoiminomethyl)amino>-2',3'-(1-methylethylidene)-5'-deoxyadenosine
• Synonyms: 5'-<(aminoiminomethyl)amino>-2',3'-(1-methylethylidene)-5'-deoxyadenosine
• CAS NO: 34245-63-1
• Molecular Weight: 348.365
• Mol File: 34245-63-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5'-<(aminoiminomethyl)amino>-2',3'-(1-methylethylidene)-5'-deoxyadenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-<(aminoiminomethyl)amino>-2',3'-(1-methylethylidene)-5'-deoxyadenosine(34245-63-1)
• EPA Substance Registry System: 5'-<(aminoiminomethyl)amino>-2',3'-(1-methylethylidene)-5'-deoxyadenosine(34245-63-1)

Safety Data

• Hazardous Substances Data: 34245-63-1(Hazardous Substances Data)

Upstream product

• 1071-37-0 2-ethylisothiourea hydrobromide 
• 21950-36-7 5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine 

Relevant articles and documents

Synthesis and Biochemical Properties of Chemically Stable Product Analogues of the Reaction Catalyzed by S-Adenosyl-L-methionine Decarboxylase

Structural analogues of decarboxylated S-adenosyl-L-methionine (dc-SAM), product of the reaction catalyzed by S-adenosyl-L-methionine decarboxylase (SAM-DC), with modifications in the side-chain portion of the molecule have been synthesized, and their ability to inhibit SAM-DC has been investigated.Mainly, compounds with a nitrogen atom in place of the sulfur were investigated.The data from these inhibition studies have resulted in a delineation of the structural features required for binding on SAM-DC.It was concluded that a terminal primary amino group, a terminal carboxyl group, and the sulfonium functionality are not required for binding on SAM-DC.It was also found that analogues of dc-SAM in which replacement of the sulfur by nitrogen was the only modification were still able to form an azomethine with the enzyme.As found for SAM and dc-SAM, these compounds also caused a time-dependent inactivation of SAM-DC.