3426-35-5

Usage

Molecular Structure

1H-Pyrazole-5-carbonitrile, 4,5-dihydro-1,3-diphenylconsists of a pyrazole ring, a carbonitrile group (-CN), and two phenyl groups (C6H5) attached to the pyrrole ring.

Molecular Weight

247.30 g/mol

Appearance

It is likely a solid with a characteristic appearance, which may vary depending on the method of synthesis and purification.

Solubility

The compound may have varying solubility in different solvents, such as polar solvents (e.g., DMSO, methanol) and non-polar solvents (e.g., dichloromethane, toluene).

Stability

The compound may be stable under certain conditions, such as temperature, pressure, and the presence of specific reagents or catalysts.

Reactivity

1H-Pyrazole-5-carbonitrile, 4,5-dihydro-1,3-diphenylmay react with various reagents to form new compounds, such as through nucleophilic or electrophilic substitution reactions.

Synthesis

The compound can be synthesized through various methods, such as condensation reactions, cyclization reactions, or other organic synthesis techniques.

Pharmaceutical Applications

Due to its structural features, the compound can be used in the synthesis of various pharmaceutical compounds, potentially leading to the development of new drugs.

Organic Synthesis Intermediate

The compound may serve as an intermediate in organic synthesis, providing a versatile building block for the creation of other complex molecules.

Research and Development

The compound's properties may make it useful in research and development in fields such as medicine, pharmacology, and biochemistry.

Scientific and Industrial Applications

The specific chemical properties and potential uses of 1H-Pyrazole-5-carbonitrile, 4,5-dihydro-1,3-diphenylmay make it valuable in various scientific and industrial applications, such as drug discovery, chemical manufacturing, or material science.

Upstream product

• 107-13-1 acrylonitrile 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 
• 588-64-7 benzaldehyde phenylhydrazone 

Downstream Products

• 24652-31-1 1,3-diphenyl-1H-pyrazole-5-carbonitrile 
• 964-42-1 1,3-diphenyl-1H-pyrazole-5-carboxylic acid 
• 1448593-91-6 3-(1,3-diphenyl-4,5-dihydro-1H-pyrazol-5-yl)-5-phenyl-1,2,4-oxadiazole 
• 1448593-92-7 5-(4-chlorophenyl)-3-(1,3-diphenyl-4,5-dihydro-1H-pyrazol-5-yl)-1,2,4-oxadiazole 
• 1448593-93-8 3-(1,3-diphenyl-4,5-dihydro-1H-pyrazol-5-yl)-5-(2-methoxyphenyl)-1,2,4-oxadiazole 
• 1448593-94-9 5-(3,4-dimethoxyphenyl)-3-(1,3-diphenyl-4,5-dihydro-1H-pyrazol-5-yl)-1,2,4-oxadiazole 
• 1448594-07-7 3-(1,3-diphenyl-1H-pyrazol-5-yl)-5-phenyl-1,2,4-oxadiazole 
• 1404223-18-2 (5Z)-4,5-dihydro-N’-hydroxy-1,3-diphenyl-1H-pyrazole-5-carboxamidine 

Relevant academic research and scientific papers

Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: Synthesis and pharmacological screening

A novel series of pyrazoline amidoxime (2a-d) and pyrazoly-1,2,4-oxadiazole (3a-p) and (4) of pharmacological significance have been synthesised. Structures of newly synthesised compounds were characterized by spectral studies. New compounds were screened

The synthesis of cross-linked poly[styrene(iodoso diacetate)] and application in preparation of pyrazoline

The 2% cross-linked poly[styrene(iodoso diacetate)] was synthesized, which was applied effectively to the synthesis of pyrazoline derivative, and can be regenerated and reused for the same reaction.

Hypervalent iodine in synthesis: XIX. Oxidation of aldehyde hydrazones with phenyliodine diacetate: A new method for the generation of nitrilimines

Oxidation of aldehyde hydrazones with phenyliodine diacetate (PID) generated nitrilimines which were trapped by acrylonitrile to give 1,3-disubstituted 2-pyrazoline-5-carbonitriles in good yields.

CHLORAMINE-T IN HETEROCYCLIC SYNTHESIS; A SIMPLE PROCEDURE FOR THE GENERATION OF NITRILIMINES AND ITS APPLICATION TO THE SYNTHESIS OF PYRAZOLINES

A new method of generating nitrilimines is described.It involves the reaction of aromatic as well as aliphatic aldehyde hydrazones with chloramine-T.In the presence of olefins pyrazolines are obtained in good yield.

Formation of 1,2,4-Triazoles by Cation Radical Induced Oxidative Addition of Arylhydrazones of Benzaldehyde and Butyraldehyde to Nitriles

1,3,5-Trisubstituted 1,2,4-triazoles have been made in excellent yields by oxidative cycloaddition of arylhydrazones of benzaldehyde and butyraldehyde to aceto-, propio-, and acrylonitrile.Oxidation was achieved with the cation radicals thianthrenyl perchlorate (Th(radical)+ClO4-) and tris(2,4-dibromophenyl)aminium hexachloroantimonate (Ar3N(radical)+SbCl6-).The triazoles thus had a phenyl, p-nitrophenyl, or 2,4-dinitrophenyl group in the 1-position, either a phenyl or propyl group in the 3-position, and a methyl, ethyl, or vinyl group in the 5-position.The formation of 5-vinyltriazoles was confirmed by their hydrogenation to 5-ethyltriazoles, which were obtained also by cycloadditions to propionitrile.New triazoles (eight) were also synthesized by a known alternative route, but in lower yields.The fact that 5-vinyltriazoles were formed instead of 5-cyano-2-pyrazolines shows that cation radical induced cycloadditions do not go through the nitrilimines.Cycloadditions with N-phenylbenzohydrazonoyl chloride and acrylonitrile in the presence of aluminum chloride and of triethylamine were carried out for comparison with the corresponding cation radical reaction.

A ONE STEP SYNTHESIS OF 4-CYANOPYRAZOLES

Reaction of nitrilimines 2 with fumaronitrile 6 yielded 4-cyanopyrazoles 8 in good yields.The structures of 8 were substantiated by comparison with their regioisomers 5-cyanopyrazoles 5, prepared by addition of 2 to acrylonitrile followed by oxidation of