342622-13-3Relevant academic research and scientific papers
Mechanistic diversity of the van Leusen reaction applied to 6-ketomorphinans and synthetic potential of the resulting acrylonitrile substructures
Schuetz, Johannes,Windisch, Petra,Kristeva, Elka,Wurst, Klaus,Ongania, Karl-Hans,Horvath, Ulrike E. I.,Schottenberger, Herwig,Laus, Gerhard,Schmidhammer, Helmut
, p. 5323 - 5326 (2005)
Tosylmethyl isocyanide was used to convert 7,8-didehydro-6-ketomorphinans to 6,7-didehydromorphinan-6-carbonitriles with retainment of the 4,5-epoxy ring. However, ring opening occurred in the presence of NaH giving 5,6,7,8-tetradehydromorphinan-6-carboni
