342630-71-1

Upstream product

• 106568-80-3 3',5'-di-O-acetyl-O⁶-triisopropylbenzenesulfonyl-2'-deoxyinosine 
• 106568-79-0 9-(3',5'-di-O-acetyl-2'-deoxy-β-D-erythro-pentofuranosyl)-1H-purine-6(9H)-one 
• 890-38-0 2-deoxyinosine 
• 342630-67-5 3',5'-Di-O-isobutyryl-N⁶-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxyadenosine 
• 114988-12-4 9-(2'-deoxy-3',5'-di-O-isobutyryl-β-D-erythro-pentofuranosyl)-6-O-<(2,4,6-triisopropylphenyl)sulfonyloxy>-9H-purine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 342630-69-7 N⁶-(1-Oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxyadenosine 

Relevant academic research and scientific papers

TEMPO-derived spin labels linked to the nucleobases adenine and cytosine for probing local structural perturbations in DNA by EPR spectroscopy

Three 2'-deoxynucleosides containing semi-flexible spin labels, namely TA, UA and UC, were prepared and incorporated into deoxyoligonucleotides using the phosphoramidite method. All three nucleosides contain 2,2,6,6-tetram

Preparation of spin-labeled 2-amino-dA, dA, dC and 5-methyl-dC phosphoramidites for the automatic synthesis of EPR active oligonucleotides

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (TEMPO) labeled phosphoramidites of 2-amino-dA, dA, dC and 5-methyl-dC were synthesized and used for the automatic synthesis of mono-labeled oligodeoxynucleotides (ODNs), which proved active to EPR. It is now possibile to insert a paramagnetic probe into nucleic acids in a site- and type-specific manner. The combination of this synthetic approach with EPR spectroscopy can be exploited for performing studies on dynamics and local structural modifications in nucleic acids.