34264-13-6Relevant academic research and scientific papers
Chalcomer assembly of optical chemosensors for selective Cu2+ and Ni2+ ion recognition
Singh, Gurjaspreet,Singh, Jandeep,Mangat, Satinderpal Singh,Singh, Jasbhinder,Rani, Sunita
, p. 12644 - 12654 (2015)
The o-, m- and p-isomeric units of chalconyl triazole-based, caged organosilicon complexes were efficiently synthesized and explored for their cationic chemosensing activities. The UV-vis spectral studies performed show considerable variations in absorpti
Unravelling the potency of triazole analogues for inhibiting α-synuclein fibrillogenesis andin vitrodisaggregation
Maqbool, Mudasir,Gadhavi, Joshna,Singh, Anju,Hivare, Pravin,Gupta, Sharad,Hoda, Nasimul
, p. 1589 - 1603 (2021)
A series of triazole-based compounds was synthesized using a click chemistry approach and evaluated for the inhibition of α-synuclein (α-syn) fibrillogenesis and its disaggregation. CompoundsTr3,Tr7,Tr12,Tr15, andTr16exhibited good effect in inhibiting α-
Heteroaryl chalcone allied triazole conjugated organosilatranes: Synthesis, spectral analysis, antimicrobial screening, photophysical and theoretical investigations
Singh, Gurjaspreet,Arora, Aanchal,Rani, Sunita,Maurya, Indresh Kumar,Aulakh, Darpandeep,Wriedt, Mario
, p. 82057 - 82081 (2016)
A series of heteroaryl tethered triazole conjoined organosilatranes were synthesized following an archetypal click reaction. The reaction sequence follows the initial generation of acetylinic Schiff bases (3a-3c, 4a-4c) which undergo 3 + 2 cycloaddition w
Molecular docking studies on COVID-19 and antibacterial evaluation of newly synthesized 4-(methoxymethyl)-1,2,3-triazolean analogues derived from (E)-1-phenyl-3-(2-(piperidin-1-yl)quinolin-3-yl) prop-2-en-1-one
Jalapathi, P.,Nagamani, M.,Srinivas, M.,Vishnu, T.
, (2021/08/18)
A series of novel quinolone-based 4-(methoxymethyl)-1,2,3-triazole derivatives were synthesized, and their structures were characterized by 1H, 13C NMR and mass spectroscopy. The compounds (IXa-l) were screened in vitro antibacterial
Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase
Kumar, Bhupinder,Kumar, Vijay,Prashar, Vikash,Saini, Suresh,Dwivedi, Ashish Ranjan,Bajaj, Beenu,Mehta, Devashish,Parkash, Jyoti,Kumar, Vinod
, p. 221 - 234 (2019/06/05)
Alzheimer's disease (AD) is a multifactorial neurological disorder involving complex pathogenesis. Single target directed drugs proved ineffective and since last few years' different pharmacological strategies including multi-targeting agents are being ex
Design, synthesis and biological evaluation of chalconyl blended triazole allied organosilatranes as giardicidal and trichomonacidal agents
Singh, Gurjaspreet,Arora, Aanchal,Mangat, Satinderpal Singh,Rani, Sunita,Kaur, Hargobinder,Goyal, Kapil,Sehgal, Rakesh,Maurya, Indresh Kumar,Tewari, Rupinder,Choquesillo-Lazarte, Duane,Sahoo, Subash,Kaur, Navneet
, p. 287 - 300 (2015/12/23)
A series of chalconyl blended triazole allied silatranes (7a-g/8a-g/9a-g) were synthesized in good yields using a simple, economical and biocompatible synthetic route. The blend of three different pharmacologically active moieties into a single scaffold r
Synthetic investigations and photo-physical properties of 1,2,3-triazole encapped chalconyl substituted organotriethoxysilanes
Singh, Gurjaspreet,Arora, Aanchal,Mangat, Satinderpal Singh,Singh, Jandeep,Rani, Sunita,Kaur, Navneet
, p. 6 - 15 (2015/01/09)
Organotriethoxysilanes (OTES) play an impressive role in the designing of organic-inorganic hybrid materials. The highly efficient copper catalysed 'Click Silylation' is followed for the functionalization of 3-azidopropyltriethoxysilane (AzPTES) with a se
Synthetic approach towards 'click' modified chalcone based organotriethoxysilanes; UV-Vis study
Singh, Gurjaspreet,Singh, Jandeep,Mangat, Satinderpal Singh,Arora, Aanchal
, p. 60853 - 60865 (2015/02/19)
The efficient linkage of a conjugate chalcone to n-propyltriethoxysilanes (nPTES) via a 1,2,3-triazole with good yields is reported. The synthesis involves a Claisen-Schmidt condensation reaction followed by a copper(i) catalyzed azide-alkyne cycloadditio
Microwave-assisted copper azide alkyne cycloaddition (CuAAC) reaction using D-glucose as a better alternative reductant
Kumar, Yogesh,Bahadur, Vijay,Singh, Anil K.,Parmar, Virinder S.,Singh, Brajendra K.
, p. 1893 - 1903 (2014/01/17)
D-Glucose has been established as a reducing agent for the copper azide alkyne cycloaddition (CuAAC) reactions. Efficacy of this new reductant has been established against various phenyl acetylenes (14 examples) and aryl azides (16 examples). All reaction
Synthesis, antimalarial and antitubercular activity of acetylenic chalcones
Hans, Renate H.,Guantai, Eric M.,Lategan, Carmen,Smith, Peter J.,Wan, Baojie,Franzblau, Scott G.,Gut, Jiri,Rosenthal, Philip J.,Chibale, Kelly
supporting information; experimental part, p. 942 - 944 (2010/06/22)
A series of acetylenic chalcones were evaluated for antimalarial and antitubercular activity. The antimalarial data for this series suggests that growth inhibition of the W2 strain of Plasmodium falciparum can be imparted by the introduction of a methoxy
