34272-02-1Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of a highly water-soluble psoralen-based photosensitizer
Uruma, Yoshiyuki,Nonomura, Takuya,Yen, Priscilla Yoong Mei,Edatani, Marie,Yamamoto, Ryotaro,Onuma, Kunishige,Okada, Futoshi
, p. 2372 - 2377 (2017)
In recent years, photodynamic therapy (PDT) has been approved for treating various medical conditions, including cancer. PDT is a treatment that employs a particular drugs, called photosensitizers which work along with specific light source. The growth of this medical industry is expanding as it is another promising alternative to treat cancer which lessen the burden of treatments in patients. This includes the benefits of minimally invasive procedures and delivering high accuracy in targeting mutations. In recent two decades, cancer researchers have produced remarkable studies on developing photosensitizers that enhance understanding of biology and genetics of cancer. It is unfortunate that not all PDT can work as well as other profound treatment because PDT has various limitations like PDT leads photosensitivity reaction that arises when the photosensitizer remains in the body for a long period of time. In this paper, our studies centers on synthesizing a highly soluble photosensitizing agent with improved effectiveness on detecting cancer cells.
Robust synthesis of sugar-coumarin based fluorescent 1,4-disubstituted-1,2,3-triazoles using highly efficient recyclable citrate grafted β-cyclodextrin@magnetite nano phase transfer catalyst in aqueous media
Jain, Yachana,Kumari, Mitlesh,Agarwal, Madhu,Gupta, Ragini
, (2019)
Green synthesis of 1,4-disubstituted-1,2,3-triazoles via click reaction using nano magnetic Fe3O4 core decorated with cyclodextrin-citric acid (Fe3O4@CD-CIT) acting as a phase transfer nanoreactor with low coppe
Design, synthesis and biological evaluation of acridone glycosides as selective BChE inhibitors
Bi, Jingjing,Gao, Yangguang,Ma, Weiwei,Zhang, Guisheng,Zhao, Chuanfang
, (2020)
Based on structure analyses of butyrylcholinesterase (BChE), a series of 21 acridone glycosides were designed, synthesized and evaluated in vitro for their BChE and acetylcholinesterase (AChE) inhibitory activities. D-ribose derivative 6f exhibited the greatest inhibitory activity on BChE (IC50 = 6.95 μM), and was the most selective inhibitor of BChE with the IC50 ratio of AChE/BChE was 20.59. D-glucose and D-galactose derivatives 6a and 6b showed inhibitory activities against both AChE and BChE. Moreover, compounds 6a, 6b, 6f and 5t were found nontoxic on SHSY5Y neuroblastoma and HepG2 cell and exhibited remarkable neuroprotective activity. Besides, compound 6f showed mixed-type inhibition against BChE (Ki = 1.76 μM), which renders 6f a potential agent for the treatment of Alzheimer's disease. These novel acridone hybrids might be used as efficient probes to reveal the relationship between ligands and BChE and pave the way for developing selective BChE inhibitors to further study the pathogenesis of alzheimer's disease.
A highly efficient and selective synthesis of 1,2,3-triazole linked saccharide nucleosides via "click chemistry"
Ding, Haixin,Yang, Ruchun,Song, Yang,Xiao, Qiang,Wu, Jun
, p. 368 - 375 (2008)
A series of 1,2,3-triazole linked saccharide nucleosides were synthesized in high yield and selectivity via "click chemistry" of the 3'-azido-2'-deoxythymidine and the propargyl carbohydrates. (Chemical Presented). Copyright Taylor & Francis Group, LLC.
Synthesis of carboranyl derivatives of alkynyl glycosides as potential BNCT agents
Giovenzana, Giovanni Battista,Luigi, Lay,Monti, Diego,Palmisano, Giovanni,Panza, Luigi
, p. 14123 - 14136 (1999)
A series of amphiphilic carbohydrate-carborane hybrids consisting of a lipophilic core (carborane cage) and a glycoside moiety for conferring high- affinity recognition by the cellular lectins have been prepared in a chemically accessible fashion.
Copper-catalyzed one-pot synthesis of glycosylated iminocoumarins and 3-triazolyl-2-iminocoumarins
Mandal, Pintu Kumar
, p. 5803 - 5814 (2014)
A general strategy was developed for the synthesis of glycosyl iminocoumarins (5a-x) in a one-pot, copper-catalyzed multicomponent reaction involving a domino reaction of sulfonyl azides, sugar alkynes, and salicylaldehydes via ketenimine intermediate for
Sequence-controlled multi-block glycopolymers to inhibit DC-SIGN-gp120 binding
Zhang, Qiang,Collins, Jennifer,Anastasaki, Athina,Wallis, Russell,Mitchell, Daniel A.,Becer, C. Remzi,Haddleton, David M.
, p. 4435 - 4439 (2013)
Chain of command: Multi-block glycopolymers made of mannose (M, see figure), glucose, and di(ethylene glycol) ethyl ether (D) monomers were synthesized using a technique to control the polymer sequence. These highly monodisperse glycopolymers were then tested for binding and inhibition of DC-SIGN, a protein important for HIV infection. Copyright
Fluorescent sugar and uridine conjugates of 1,8-naphthalimides with methyl and ferrocenyl headgroups
Cavigiolio, Giorgio,Morgan, Joy L.,Robinson, Brian H.,Simpson, Jim
, p. 885 - 894 (2004)
The first amphiphilic sugar and deoxyuridine conjugates with a 4-ethynyl-1,8-N-methylnaphthalimide linker, a 4-ethynyldeoxyuridine conjugate with a N-undecylferrocenyl headgroup, and a 1,8-naphthalimide with a 2,3,4,6-tetra-O-acetate-β-D-glucopyranoside h
BORON CLUSTER-COUPLED COMPOUND
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Paragraph 0169; 0171-0173, (2021/03/05)
To provide a novel boron-containing compound which increases intratumorous accumulation and tumor retention, and is efficiently taken into a tumor cell.SOLUTION: The present invention relates to a compound represented by formula (I) in the figure or a salt thereof. [In the formula, X represents a divalent to pentavalent organic group; Y represents a linker structure; R represents a monovalent group comprising boron clusters; and n represents 2, 3, 4 or 5.SELECTED DRAWING: None
Synthesis of functionalized copillar[4+1]arenes and rotaxane as heteromultivalent scaffolds
Chen, Wenzhang,Mohy Ei Dine, Tharwat,Vincent, Stéphane P.
supporting information, p. 492 - 495 (2021/01/25)
In this study, novel copillar[4+1]arenes were used as central heteromultivalent scaffolds via orthogonal couplings with a series of biologically relevant molecules such as carbohydrates, α-amino acids, biotin and phenylboronic acid. Further modifications by introducing maleimides or cyclooctyne groups provided molecular probes adapted to copper-free click chemistry. An octa-azidated fluorescent rotaxane bearing two distinct ligands was also generated in a fully controlled manner.
