34272-02-1Relevant articles and documents
Design, synthesis, and biological evaluation of a highly water-soluble psoralen-based photosensitizer
Uruma, Yoshiyuki,Nonomura, Takuya,Yen, Priscilla Yoong Mei,Edatani, Marie,Yamamoto, Ryotaro,Onuma, Kunishige,Okada, Futoshi
, p. 2372 - 2377 (2017)
In recent years, photodynamic therapy (PDT) has been approved for treating various medical conditions, including cancer. PDT is a treatment that employs a particular drugs, called photosensitizers which work along with specific light source. The growth of this medical industry is expanding as it is another promising alternative to treat cancer which lessen the burden of treatments in patients. This includes the benefits of minimally invasive procedures and delivering high accuracy in targeting mutations. In recent two decades, cancer researchers have produced remarkable studies on developing photosensitizers that enhance understanding of biology and genetics of cancer. It is unfortunate that not all PDT can work as well as other profound treatment because PDT has various limitations like PDT leads photosensitivity reaction that arises when the photosensitizer remains in the body for a long period of time. In this paper, our studies centers on synthesizing a highly soluble photosensitizing agent with improved effectiveness on detecting cancer cells.
Robust synthesis of sugar-coumarin based fluorescent 1,4-disubstituted-1,2,3-triazoles using highly efficient recyclable citrate grafted β-cyclodextrin@magnetite nano phase transfer catalyst in aqueous media
Jain, Yachana,Kumari, Mitlesh,Agarwal, Madhu,Gupta, Ragini
, (2019)
Green synthesis of 1,4-disubstituted-1,2,3-triazoles via click reaction using nano magnetic Fe3O4 core decorated with cyclodextrin-citric acid (Fe3O4@CD-CIT) acting as a phase transfer nanoreactor with low coppe
Design, synthesis and biological evaluation of acridone glycosides as selective BChE inhibitors
Bi, Jingjing,Gao, Yangguang,Ma, Weiwei,Zhang, Guisheng,Zhao, Chuanfang
, (2020)
Based on structure analyses of butyrylcholinesterase (BChE), a series of 21 acridone glycosides were designed, synthesized and evaluated in vitro for their BChE and acetylcholinesterase (AChE) inhibitory activities. D-ribose derivative 6f exhibited the greatest inhibitory activity on BChE (IC50 = 6.95 μM), and was the most selective inhibitor of BChE with the IC50 ratio of AChE/BChE was 20.59. D-glucose and D-galactose derivatives 6a and 6b showed inhibitory activities against both AChE and BChE. Moreover, compounds 6a, 6b, 6f and 5t were found nontoxic on SHSY5Y neuroblastoma and HepG2 cell and exhibited remarkable neuroprotective activity. Besides, compound 6f showed mixed-type inhibition against BChE (Ki = 1.76 μM), which renders 6f a potential agent for the treatment of Alzheimer's disease. These novel acridone hybrids might be used as efficient probes to reveal the relationship between ligands and BChE and pave the way for developing selective BChE inhibitors to further study the pathogenesis of alzheimer's disease.
A highly efficient and selective synthesis of 1,2,3-triazole linked saccharide nucleosides via "click chemistry"
Ding, Haixin,Yang, Ruchun,Song, Yang,Xiao, Qiang,Wu, Jun
, p. 368 - 375 (2008)
A series of 1,2,3-triazole linked saccharide nucleosides were synthesized in high yield and selectivity via "click chemistry" of the 3'-azido-2'-deoxythymidine and the propargyl carbohydrates. (Chemical Presented). Copyright Taylor & Francis Group, LLC.
Synthesis of carboranyl derivatives of alkynyl glycosides as potential BNCT agents
Giovenzana, Giovanni Battista,Luigi, Lay,Monti, Diego,Palmisano, Giovanni,Panza, Luigi
, p. 14123 - 14136 (1999)
A series of amphiphilic carbohydrate-carborane hybrids consisting of a lipophilic core (carborane cage) and a glycoside moiety for conferring high- affinity recognition by the cellular lectins have been prepared in a chemically accessible fashion.
Copper-catalyzed one-pot synthesis of glycosylated iminocoumarins and 3-triazolyl-2-iminocoumarins
Mandal, Pintu Kumar
, p. 5803 - 5814 (2014)
A general strategy was developed for the synthesis of glycosyl iminocoumarins (5a-x) in a one-pot, copper-catalyzed multicomponent reaction involving a domino reaction of sulfonyl azides, sugar alkynes, and salicylaldehydes via ketenimine intermediate for
Sequence-controlled multi-block glycopolymers to inhibit DC-SIGN-gp120 binding
Zhang, Qiang,Collins, Jennifer,Anastasaki, Athina,Wallis, Russell,Mitchell, Daniel A.,Becer, C. Remzi,Haddleton, David M.
, p. 4435 - 4439 (2013)
Chain of command: Multi-block glycopolymers made of mannose (M, see figure), glucose, and di(ethylene glycol) ethyl ether (D) monomers were synthesized using a technique to control the polymer sequence. These highly monodisperse glycopolymers were then tested for binding and inhibition of DC-SIGN, a protein important for HIV infection. Copyright
Fluorescent sugar and uridine conjugates of 1,8-naphthalimides with methyl and ferrocenyl headgroups
Cavigiolio, Giorgio,Morgan, Joy L.,Robinson, Brian H.,Simpson, Jim
, p. 885 - 894 (2004)
The first amphiphilic sugar and deoxyuridine conjugates with a 4-ethynyl-1,8-N-methylnaphthalimide linker, a 4-ethynyldeoxyuridine conjugate with a N-undecylferrocenyl headgroup, and a 1,8-naphthalimide with a 2,3,4,6-tetra-O-acetate-β-D-glucopyranoside h
A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning
Baati, Rachid,Coisne, Caroline,Courageux, Charlotte,Dehouck, Marie-Pierre,Gastellier, Anne-Julie,Gosselet, Fabien,Hanak, Anne-Sophie,Jean, Ludovic,Landry, Christophe,Nachon, Florian,Probst, Nicolas,Renard, Pierre-Yves,Warnault, Pierre,Calas, André-Guilhem,Da Silva, Ophélie,Dias, José,Trancart, Marilène
supporting information, (2022/03/16)
Recent events demonstrated that organophosphorus nerve agents are a serious threat for civilian and military populations. The current therapy includes a pyridinium aldoxime reactivator to restore the enzymatic activity of acetylcholinesterase located in the central nervous system and neuro-muscular junctions. One major drawback of these charged acetylcholinesterase reactivators is their poor ability to cross the blood-brain barrier. In this study, we propose to evaluate glucoconjugated oximes devoid of permanent charge as potential central nervous system reactivators. We determined their in vitro reactivation efficacy on inhibited human acetylcholinesterase, the crystal structure of two compounds in complex with the enzyme, their protective index on intoxicated mice, and their pharmacokinetics. We then evaluated their endothelial permeability coefficients with a human in vitro model. This study shed light on the structural restrains of new sugar oximes designed to reach the central nervous system through the glucose transporter located at the blood-brain barrier.
Exploring the Biochemical Foundations of a Successful GLUT1-Targeting Strategy to BNCT: Chemical Synthesis and in Vitro Evaluation of the Entire Positional Isomer Library of ortho-Carboranylmethyl-Bearing Glucoconjugates
Matovi?, Jelena,J?rvinen, Juulia,Sokka, Iris K.,Imlimthan, Surachet,Raitanen, Jan-Erik,Montaser, Ahmed,Maaheimo, Hannu,Huttunen, Kristiina M.,Per?niemi, Sirpa,Airaksinen, Anu J.,Sarparanta, Mirkka,Johansson, Mikael P.,Rautio, Jarkko,Ekholm, Filip S.
, p. 285 - 304 (2020/12/21)
Boron neutron capture therapy (BNCT) is a noninvasive binary therapeutic modality applicable to the treatment of cancers. While BNCT offers a tumor-targeting selectivity that is difficult to match by other means, the last obstacles preventing the full har
