34274-23-2

Basic information

• Product Name: 4(1H)-Pyrimidinone, 2-(methoxymethyl)- (9CI)
• Synonyms: 4(1H)-Pyrimidinone, 2-(methoxymethyl)- (9CI);2-(Methoxymethyl)pyrimidin-4(3H)-one;2-Methoxymethyl-pyrimidin-4-ol
• CAS NO: 34274-23-2
• Molecular Formula: C6H8N2O2
• Molecular Weight: 140.13992
• Product Categories: PYRIMIDINE
• Mol File: 34274-23-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4(1H)-Pyrimidinone, 2-(methoxymethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyrimidinone, 2-(methoxymethyl)- (9CI)(34274-23-2)
• EPA Substance Registry System: 4(1H)-Pyrimidinone, 2-(methoxymethyl)- (9CI)(34274-23-2)

Safety Data

• Hazardous Substances Data: 34274-23-2(Hazardous Substances Data)

Upstream product

• 1903-91-9 2-methoxyethanimidamide hydrochloride 

Downstream Products

• 105950-89-8 4-chloro-2-(methoxymethyl)pyrimidine 

Relevant articles and documents

Compounds for treating and preventing diabetic complications

This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, wherein R is as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds and methods of treating or preventing diabetic complications, particularly diabetic neuropathy, diabetic nephropathy and diabetic cardiomyopathy by administering such compounds to a mammal suffering from diabetes and therefore at risk for developing such complications. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an aldose reductase inhibitor and to methods of treating or preventing diabetic complications therewith. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor and to methods of treating cardiomyopathy and other heart-related problems therewith. This invention is also directed to certain intermediates used in the synthesis of the compounds of formula I and to processes for preparing those intermediates.

Substituted pyrimidine derivatives, a process for the preparation thereof and the use thereof as reagents

Pyrimidine derivatives of the formula I STR1 in which R1, R2, X and Y have the stated meaning, the salts thereof and a process for the preparation thereof are described. Because of their sorbitol-accumulating activity, they are suitable for use as reagents for an advantageous pharmacological screening model for testing aldose reductase inhibitors.

Pyrimidylalkylthio benzimidale compounds, pharmaceutical compositions and use

This invention relates to 2- and 4-pyrimidinylmethylsulphinyl(and thio)benzimidazoles in which the pyrimidyl group is substituted by an optionally substituted amino group. These compounds inhibit exogenously and endogenously stimulated gastric acid secretion.