342788-24-3Relevant academic research and scientific papers
Utility of arylhydrazidoyl aryl ethers in heterocycles: A novel synthesis of aryloxypyridazines, phthalazines and thieno[3,4-d]pyridazine derivatives
Ibrahim, M. K. A.,Elghandour, A. H. H.,El-Badry, B.
, p. 612 - 616 (2007/10/03)
The reaction of hydrazidoyl chloride 1 with p-bromophenol afford the ether derivative 2 which on treatment with ethyl cyanoacetate furnish 6-(4-bromophenyloxy)-4-cyano-2,3-dihydro-5-methyl-2-phenyl-3-pyridazinone. Compound 3 is then utilized to synthesize a variety of heterocyclic compounds such as phthalazine derivatives, 6a-c, 10a,b, 12 and 14. Also, it is utilized in the synthesis of thieno[3,4-d]pyridazine derivative 15, which undergoes chemical transformations to afford several new heterocyclic compounds. All structures have been established on the basis of elemental analyses and spectral data.
