342798-45-2Relevant academic research and scientific papers
Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes
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Page/Page column 34, (2010/02/15)
This invention provides quinazolines that are useful for treating cell proliferative diseases and disorders, such as cardiovascular diseases, infections, cancers, autoimmune diseases, gout, kidney disease, and neurodegenerative diseases and disorders such
2-Aminoquinazoline inhibitors of cyclin-dependent kinases
Bathini, Yadagiri,Singh, Inderjit,Harvey, Patricia J.,Keller, Paul R.,Singh, Rajeshwar,Micetich, Ronald G.,Fry, David W.,Dobrusin, Ellen M.,Toogood, Peter L.
, p. 3881 - 3885 (2007/10/03)
The inhibition of cyclin-dependent kinase 4 (Cdk4) causes cell cycle arrest and restores a checkpoint that is absent in the majority of tumor cells. Compounds that inhibit Cdk4 selectively are targeted for treating cancer. Appropriate substitution of 2-aminoquinazolines is demonstrated to produce high levels of selectivity for Cdk4 versus closely related serine-threonine kinases.
