34280-00-7

Upstream product

• 53784-33-1 2,3,4-tri-O-acetyl-1-azido-1-deoxy-β-D-xylopyranose 
• 1233-03-0 α-D-xylopyranose tetraacetate 
• 3068-31-3 1-bromo-2,3,4-tri-O-acetyl-α-D-xylopyranose 
• 536-74-3 phenylacetylene 

Relevant academic research and scientific papers

Synthesis of 1,2,3-triazoles from xylosyl and 5-thioxylosyl azides: Evaluation of the xylose scaffold for the design of potential glycogen phosphorylase inhibitors

Various acetylenic derivatives and acetylated β-d-xylopyranosyl azide or the 5-thio-β-d-xylopyranosyl analogue were coupled by Cu(I)-catalyzed azide alkyne 1,3-dipolar cycloaddition (CuAAC) to afford a series of 1-xylosyl-4-substituted 1,2,3-triazoles. Controlled oxidation of the endocyclic sulfur atom of the 5-thioxylose moiety led to the corresponding sulfoxides and sulfones. Deacetylation afforded 19 hydroxylated xylose and 5-thioxylose derivatives, found to be only sparingly water-soluble. Compared to glucose-based analogues, they appeared to be much weaker inhibitors of glycogen phosphorylase, as the absence of a hydroxymethyl group weakens their binding at the enzyme active site. However, such new xylose derivatives might be useful glycomimetics.

Evaluation of bis-triphenylphosphano-copper(I)-butyrate (C 3H7COOCu(PPh3)2) as catalyst for the synthesis of 1-glycopyranosyl-4-substituted-1,2,3-triazoles

Bis-triphenylphosphano-copper(I)-butyrate (C3H 7COOCu(PPh3)2) was applied for the synthesis of O-peracylated 1-glycopyranosyl-4-substituted-1,2,3-triazoles from the corresponding glycosyl azides and alkynes. Thi

Direct synthesis of 1,4-disubstituted-5-alumino-1,2,3-triazoles: Copper-catalyzed cycloaddition of organic azides and mixed aluminum acetylides

Chemical Equation Presented Al together now: Aluminotriazoles are obtained in a fully chemo- and regioselective manner by a copper-catalyzed cycloaddition of organic azides with mixed-aluminum acetylides (see scheme). The carbon-aluminum bond, which is unaffected by the first transformation, is still able to react further with different electrophiles.