34282-25-2Relevant academic research and scientific papers
Pharmacophore-fusing design of pyrimidine sulfonylacetanilides as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase
Chen, Fener,De Clercq, Erik,Pannecouque, Christophe,Sang, Yali,Zhuang, Chunlin
supporting information, (2020/02/03)
Twenty-seven derivatives (40–66) were generated by pharmacophore fusing of sulfonylacetanilide-diarylpyrimidine (1) with rilpivirine or biphenyl-diarylpyrimidines. They displayed up to single-digit nanomolar activity against wild-type (WT) virus and vario
Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases
Sch?nauer, Esther,Kany, Andreas M.,Haupenthal, J?rg,Hüsecken, Kristina,Hoppe, Isabel J.,Voos, Katrin,Yahiaoui, Samir,Els?sser, Brigitta,Ducho, Christian,Brandstetter, Hans,Hartmann, Rolf W.
supporting information, p. 12696 - 12703 (2017/09/25)
Secreted virulence factors like bacterial collagenases are conceptually attractive targets for fighting microbial infections. However, previous attempts to develop potent compounds against these metalloproteases failed to achieve selectivity against human
Synthesis of 1,1-Diamino-2-acylethylenes - Sulphide Contraction Route
Nair, M. D.,Desai, J. A.
, p. 4 - 7 (2007/10/02)
Triphenylphosphine-induced sulphur extrusion from phenacylthioimidazolines, tetrahydropyrimidines and their benzo analogues has been used for the synthesis of a variety of 1,1-diamino-2-acylethylenes.
