34286-34-5Relevant academic research and scientific papers
Synthesis of hydroxymethylglutathione from glutathione and L-serine catalyzed by carboxypeptidase Y.
Okumura, Ryosuke,Koizumi, Yukio,Sekiya, Jiro
, p. 434 - 437 (2003)
Hydroxymethylglutathione (gamma-L-glutamyl-L-cysteinyl-L-serine; hmGSH) occurs in many species belonging to the family Gramineae, but the biosynthetic pathway for hmGSH has not been identified. We found that carboxypeptidase Y (CPY), but not carboxypeptidase A, catalyzed hmGSH synthesis from glutathione and L-serine in vitro at acidic pH. CPY also catalyzed methylglutathione synthesis from glutathione and L-alanine. These findings suggested that a carboxypeptidase-like enzyme may be involved in hmGSH synthesis in vivo.
