342893-76-9Relevant academic research and scientific papers
Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT2C) receptor agonist without 5-HT2B agonism
Cheng, Jianjun,Kozikowski, Alan P.,McCorvy, John D.,Roth, Bryan L.,Shen, Sida,Zhang, Guiping
, (2019)
A new series of fluorinated 5-HT2C agonists were designed and synthesized on the basis of our previous work on 2-phenylcyclopropylmethylamines as a potential approach for the treatment of central nervous system disorders. Key fluorinated cyclop
Synthesis of gem-difluoromethylene building blocks through regioselective allylation of gem-difluorocyclopropanes
Munemori, Daisuke,Narita, Kent,Nokami, Toshiki,Itoh, Toshiyuki
supporting information, p. 2638 - 2641 (2014/06/09)
gem-Difluorocyclopropane derivatives react with allyltributylstannane in the presence of 2,2′-azobis(isobutyronitrile) to afford 1,6-dienes with a gem-difluoromethylene moiety at the allylic position. The reaction proceeds regioselectively with high yield
RING OPENING REACTION OF gem-DIFLUOROCYCLOPROPYL KETONES WITH NUCLEOPHILES
Kobayashi, Yoshiro,Taguchi, Takeo,Morikawa, Tsutomu,Takase, Toyohiko,Takanashi, Hiroshi
, p. 1047 - 1050 (2007/10/02)
Syntheses of gem-difluorocyclopropyl ketones (3a-d) and their reactions with nucleophiles are described.Ring opening reactions of 3a, c and d with a methanolate and a thiolate anion took entirely different courses of bond scission of the cyclopropane ring.
