34298-84-5

Usage

Uses

Used in Pharmaceutical Industry:
2-(1H-INDOL-5-YL)ACETIC ACID is used as a pharmaceutical agent for its potential anti-cancer and anti-inflammatory properties. Its ability to modulate various biological processes makes it a promising candidate for the development of new therapeutic agents.
Used in Plant Biology Research:
2-(1H-INDOL-5-YL)ACETIC ACID is used as a research tool in plant biology to study the mechanisms of plant growth and development. As a key component of the auxin class of plant hormones, it helps researchers understand the complex regulatory networks that control plant responses to environmental stimuli and developmental cues.
Used in Agriculture:
2-(1H-INDOL-5-YL)ACETIC ACID is used in agriculture as a plant growth regulator to enhance crop yield and quality. Its role in promoting cell elongation, apical dominance, and root initiation can be harnessed to improve plant growth and development, leading to increased productivity and more robust plants.

InChI:InChI=1/C10H9NO2/c12-10(13)6-7-1-2-9-8(5-7)3-4-11-9/h1-5,11H,6H2,(H,12,13)

Upstream product

• 33140-84-0 methyl 2-(1H-indol-5-yl)acetate 
• 209809-20-1 4-amino-3-bromophenylacetic acid methyl ester 
• 39552-81-3 methyl p-aminophenylacetate 
• 10075-50-0 5-bromo-1H-indole 

Downstream Products

• 1239447-50-7 N-(2-(3-benzoylphenyl)propyl)-2-(1H-indol-5-yl)acetamide 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUND, APPLICATION THEREOF, AND COMPOSITION CONTAINING SAME

A heterocyclic compound represented by formula XI, a pharmaceutically acceptable salt, a solvate, or a solvate of a pharmaceutically acceptable salt thereof, use thereof, and a composition containing the same. The compound is novel in structure and has good STAT5 inhibitory activity.

Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies

We report here the discovery and pharmacological characterization of N-(1-benzyl-1H-pyrazol-3-yl)-2-phenylacetamide derivatives as potent, selective, brain-penetrating T-type calcium channel blockers. Optimization focused mainly on solubility, brain penetration, and the search for an aminopyrazole metabolite that would be negative in an Ames test. This resulted in the preparation and complete characterization of compound 66b (ACT-709478), which has been selected as a clinical candidate.

TRIAZOLE COMPOUNDS AS T-TYPE CALCIUM CHANNEL BLOCKERS

The invention relates to compounds of formula (I) wherein X, Y, R1, R2, (R4)n, and (R5)m are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.

PYRAZOLE COMPOUNDS AND THEIR USE AS T-TYPE CALCIUM CHANNEL BLOCKERS

The invention relates to compounds of formula (I) Formula (I) wherein X, Y, R1, R2, (R4)n, and (R5)m are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.

Aliphatic carboxamides

This invention provides a series of novel heterocyclic aliphatic carboxamides of formula I in which the group >Z--Y--XC=CH--NN--CH=CC=N--NN--N=C and the other radicals have the meanings defined in the following specification. The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.