343221-00-1

Upstream product

• 2637-34-5 2-Sulfanylpyridine 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 109-77-3 malononitrile 
• 5688-82-4 2-(3,4,5-trimethoxybenzylidene)malononitrile 

Downstream Products

• 71870-96-7 2-Diethoxymethyl-2-(3,4,5-trimethoxy-benzyl)-malononitrile 
• 73576-24-6 2,4,6-triamino-5-(3,4,5-trimethoxybenzyl)pyrimidine 
• 71870-98-9 2-Cyano-3,3-diethoxy-2-(3,4,5-trimethoxy-benzyl)-propionimidic acid methyl ester 
• 71870-97-8 2-Cyano-3,3-diethoxy-2-(3,4,5-trimethoxy-benzyl)-propionamide 

Relevant academic research and scientific papers

An efficient green multi-component reaction strategy for the synthesis of highly functionalised pyridines and evaluation of their antibacterial activities

An efficient green multi-component reaction (MCR) method has been developed for the synthesis of 2-amino-4-aryl/heteroaryl-6-(pyridin-2-ylthio)pyridine-3, 5-dicarbonitrile(s) via a 3-component reaction of aryl aldehyde(s), malononitrile and 2-mercaptopyridine in the presence of K2CO 3 under solvent free reaction conditions (SFRC) using grinding technique at room temperature in a single step. The advantages of the present protocol is operationally simple, environmentally benign, solvent-free reaction conditions (SFRC), simple work up, excellent isolated yields of desired products and viable method for large scale applications in pharmaceutical industry. Interestingly, the synthesized compounds showed moderate to excellent antibacterial activities against Gram-positive and Gram-negative bacterial strains.

The behaviour of arylidenemalononitriles towards certain thiating phosphorus reagents

The behaviour of arylidenemalononitriles 1, 2 and 3 towards certain thiating phosphorus reagents, namely, phosphorus pentasulfide and Lawesson's reagent 10, has been outlined. The products obtained depend on the nature of reactants. Analytical and spectro