34325-71-8

Basic information

• Product Name: Acetamide, 2-bromo-N-(4-ethoxyphenyl)-
• CAS NO: 34325-71-8
• Molecular Formula: C10H12BrNO2
• Molecular Weight: 258.115
• Mol File: 34325-71-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Acetamide, 2-bromo-N-(4-ethoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2-bromo-N-(4-ethoxyphenyl)-(34325-71-8)
• EPA Substance Registry System: Acetamide, 2-bromo-N-(4-ethoxyphenyl)-(34325-71-8)

Safety Data

• Hazardous Substances Data: 34325-71-8(Hazardous Substances Data)

Upstream product

• 598-21-0 2-Bromoacetyl bromide 
• 156-43-4 4-Ethoxyaniline 

Downstream Products

• 103-97-9 Phenocoll 

Relevant articles and documents

Structural basis of binding and justification for the urease inhibitory activity of acetamide hybrids of N-substituted 1,3,4-oxadiazoles and piperidines

In present, we have performed the Michaelis–Menten kinetics studies of urease inhibitors (6a–o), having basic skeleton of acetamide hybrids of N-substituted 1,3,4-oxadiazoles and piperidines. From the Lineweaver-Burk plot, Dixon plot and their secondary replots, it has been confirmed that all the compounds have inhibited the enzyme competitively with Ki values of in range from 3.11 ± 0.2 to 5.20 ± 0.7 μM. Compound 6a was found to have lowest Ki among the series, while compounds 6d, 6e, 6gand 6i were found subsequently the excellent Ki values after 6a. Molecular docking has supported their types of inhibitions and structure activity-relationship. Most frequently, the nitro group oxygen atoms were found in contact with nickel ions of the active site. Moreover, all the compounds were subjected to toxicity tests and were found nontoxic against human neutrophils and plants, respectively.

Convergent synthesis, free radical scavenging, Lineweaver-Burk plot exploration, hemolysis and in silico study of novel indole-phenyltriazole hybrid bearing acetamides as potent urease inhibitors

In the current paper, through a convergent multi-step approach, a library of novel indole-phenyltriazole hybrids containing an amide moiety (9a-k) was synthesized. The structural verification of all synthesized molecules was accomplished by CHN and spectral analyses data. These synthesized bi-heterocyclic derivatives (9a-k) were evaluated for their anti-ulcer potential by inhibitory action against Jack bean urease enzyme and subsequently their structure-activity relationship was perceived. Moreover, these compounds were inspected for cytotoxic profile by hemolytic activity and it was professed that nearly all the synthesized compounds showed low cytotoxicity. In addition, free radical scavenging activity and kinetic analysis were also carried out for these compounds to understand their mode of inhibition. So, it was summated that these derivatives might lead to further research gateways for obtaining better and safe anti-ulcer agents.

Design, Synthesis, Antimicrobial Evaluation, and Laccase Catalysis Effect of Novel Benzofuran–Oxadiazole and Benzofuran–Triazole Hybrids

Novel structural hybrids of benzofuran–oxadiazole and benzofuran–triazole have been synthesized and evaluated for their potential against Staphylococcus aureus, Bacillus subtilis, and Escherichia coli. The excellent antibiotic activity was shown by compou