3433-38-3

Basic information

• Product Name: 2-Bromomethyl-piperidine
• Synonyms: 2-Bromomethyl-piperidine
• CAS NO: 3433-38-3
• Molecular Formula: C6H12BrN
• Molecular Weight: 178
• Mol File: 3433-38-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 191-192℃
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Bromomethyl-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromomethyl-piperidine(3433-38-3)
• EPA Substance Registry System: 2-Bromomethyl-piperidine(3433-38-3)

Safety Data

• Hazardous Substances Data: 3433-38-3(Hazardous Substances Data)

Usage

General Description

2-Bromomethyl-piperidine, also known as 2-(Bromomethyl)piperidine or 1-(2-Bromomethyl)piperidine, is a chemical compound with the formula C6H12BrN. It is a clear, colorless to pale yellow liquid that is commonly used in the synthesis of pharmaceuticals and other fine chemicals. 2-Bromomethyl-piperidine is an important intermediate in the production of various drugs, including antihistamines and antipsychotics. It is also used as a reagent in organic synthesis, particularly in the preparation of heterocyclic compounds. The compound is known to be a skin and eye irritant and can be harmful if inhaled or ingested, so proper safety precautions should be taken when handling it.

Upstream product

• 3433-37-2 piperidin-2-ylmethanol 

Downstream Products

• 1431693-89-8 dicyclohexyl(piperidin-2-ylmethyl)phosphine oxide 
• 1390625-58-7 2-((dicyclohexylphosphino)methyl)piperidine-diborane complex 

Relevant articles and documents

Catalytic hydrogenation of unactivated amides enabled by hydrogenation of catalyst precursor

A general method for catalytic hydrogenation of unactivated amides was achieved. During the catalyst induction period, a novel structural change was observed involving full hydrogenation of the interior unsaturated bonds of the pyridines of the Ru-containing catalyst precursor. Based on this observation, the mechanism of amide hydrogenation may involve a two-step pathway, wherein the Ru catalyst having an H-Ru-N-H functionality is generated in the first step, followed by the amide carbonyl group interacting with the outer, rather than the inner, sphere of the Ru catalyst.

Bicyclic β-sultams: Synthesis from monocyclic β-aminothiols and some properties

The cyclamine methanethiols 7 are prepared from the corresponding alcohols 3 and oxidatively transformed by treatment with chlorine into the cyclic substituted taurinechlorides 8. Upon treatment with bases, 8 is cyclized yielding the bicyclic β-sultams 9. Some spectroscopic properties and the solvolysis of 9 are briefly discussed.