3433-74-7

Usage

Uses

Used in Law Enforcement and Crowd Control:
5,11-dihydrodibenzo[b,e][1,4]oxazepine is used as a lacrimator for its ability to cause severe eye irritation, which is effective in controlling crowds and maintaining order during law enforcement operations.
Used in Chemical Warfare:
5,11-dihydrodibenzo[b,e][1,4]oxazepine is used as a chemical warfare agent due to its powerful and lasting effects on the human body, causing not only eye irritation but also skin and respiratory irritation, as well as nausea and vomiting when ingested.
Used in Industrial Applications:
5,11-dihydrodibenzo[b,e][1,4]oxazepine is used as a component in the production of various industrial chemicals, taking advantage of its solubility in organic solvents and its chemical properties.

Upstream product

• 97026-25-0 2[(2-bromobenzyl)oxy]aniline hydrochloride 
• 3494-23-3 2-bromobenzyl 2-nitrophenyl ether 
• 88-75-5 2-hydroxynitrobenzene 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 3434-04-6 2-(2-bromobenzyloxy)aniline 

Downstream Products

• 16882-85-2 N-(2-acetoxy-phenyl)-N-[2-(11H-dibenzo[b,e][1,4]oxazepin-5-ylmethyl)-phenyl]-acetamide 
• 16882-86-3 5-benzyl-5,11-dihydro-dibenzo[b,e][1,4]oxazepine 
• 477778-96-4 (R)-5,11-dihydro-5-[1-(3-pyrrolidinophenethyl)pyrrolidin-3-yl]dibenzo[b,e][1,4]oxazepine 
• 477778-94-2 (R)-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-3-yl]dibenzo[b,e][1,4]oxazepine 
• 195991-51-6 (R)-(+)-5,11-dihydro-5-[1-(4-fluorophenethyl)-2-pyrrolidinylmethyl]dibenzo[b,e][1,4]oxazepine 
• 1307225-08-6 1-[(4-nitrophenyl)thio]dibenzo[b,f][1,4]oxazepine 
• 281677-61-0 (R)-5,11-dihydro-5-[1-(3-methoxyphenethyl)piperidine-2-ylmethyl]dibenzo [b,e][1,4] oxazepine 

Relevant academic research and scientific papers

Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I

DNA ligases are critical components for DNA metabolism in all organisms. NAD+-dependent DNA ligases (LigA) found exclusively in bacteria and certain entomopoxviruses are drawing increasing attention as therapeutic targets as they differ in their cofactor requirement from ATP-dependent eukaryotic homologs. Due to the similarities in the cofactor binding sites of the two classes of DNA ligases, it is necessary to find determinants that can distinguish between them for the exploitation of LigA as an anti-bacterial target. In the present endeavour, we have synthesized and evaluated a series of tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives for their ability to distinguish between bacterial and human DNA ligases. The in vivo inhibition assays that employed LigA deficient E. coli GR501 and S. typhimurium LT2 bacterial strains, rescued by ATP-dependent T4 DNA ligase or Mycobacterium tuberculosis NAD+-dependent DNA ligase (Mtb LigA), respectively, showed that the compounds can specifically inhibit bacterial LigA. The in vitro enzyme inhibition assays using purified MtbLigA, human DNA ligase I & T4 DNA ligase showed specific inhibition of MtbLigA at low micromolar range. Our results demonstrate that tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can distinguish between bacterial and human DNA ligases by ～5-folds. In silico docking and enzyme inhibition assays identified that the compounds bind to the cofactor binding site and compete with the cofactor. Ethidium bromide displacement and gel-shift assays showed that the inhibitors do not exhibit any unwanted general interactions with the substrate DNA. These results set the stage for the detailed exploration of this compound class for development as antibacterials.

Elaboration of the oxazepine ring system via cuI/L-proline-catalyzed intramolecular aryl amination

A two-step approach for assembling oxazepines is described, which started from 2-aminophenols and substituted 2-bromobenzyl bromides and used CuI/L-proline-catalyzed coupling reaction as the key step. Georg Thieme Verlag Stuttgart.

An efficient assembly of heterobenzazepine ring systems utilizing an intramolecular palladium-catalyzed cycloamination

Azaheterocyclic compounds are interesting and medicinally relevant targets. Herein we disclose an improved synthesis into the oxazepine and thiazepine ring systems. The key step in the synthesis exploits recent advancements in the palladium-catalyzed amination reaction, which was utilized to form the seven-membered rings. General conditions for this reaction were Pd2dba3, P(t-Bu)3, NaO-t-Bu alone or with K2CO3, in toluene. The scope of the reaction was investigated, and has been shown to be effective on a variety of substrates as illustrated.

3-piperidyl-4-oxoquinazoline derivatives and pharmaceutical compositions comprising the same

3-piperidyl-4-oxoquinazoline derivatives are provided, which is represented by the formula (I): wherein R represents an amino group or a cyclic amino group such as dibenzoazepine, each of which is substituted with a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, or the like, n is an integer of 1 to 3, R3and R4independently represents a hydrogen atom, a lower alkyl group, or the like, or a pharmaceutically acceptable salt thereof. Compounds (I) of the present invention have excellent MTP-inhibitory activity. Thus, these compounds not only inhibit formation of LDL that is a cause of arteriosclerotic diseases but also regulate TG, cholesterol, and lipoproteins such as LDL in the blood and regulate cellular lipids through regulation of MTP activity. They can also be used as a new type of preventive or therapeutic agents for hyperlipemia or arteriosclerotic diseases. Furthermore, they can be used as therapeutic or preventive agents for pancreatitis, obesity, hypercholesterolemia, and hypertriglyceridemia.