SUGAMMADEX, also known as 6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-Cyclodextrin, is a selective relaxant binding agent used in the medical field. It is an octasaccharide derivative of gamma-cyclodextrin, where all eight primary hydroxy groups are replaced by 2-(carboxyethyl)sulfanyl groups. SUGAMMADEX is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery in adults. Used in Pharmaceutical Industry: SUGAMMADEX is used as a reversal agent for neuromuscular blocking drugs. It is particularly effective in reversing the effects of rocuronium bromide and vecuronium bromide, which are medications that cause temporary paralysis and are used for general anesthesia, ventilation, or tracheal intubation during surgery. By reversing the effects of these medications, SUGAMMADEX helps patients recover more quickly after surgery. SUGAMMADEX is used as a treatment option to improve postoperative recovery for patients who have undergone surgery requiring neuromuscular blockade. The use of SUGAMMADEX allows for a more controlled and predictable recovery process, reducing the risk of postoperative complications and enhancing patient safety. SUGAMMADEX is marketed under the brand name Bridion by Merck Sharp and Dohme and was approved by the United States FDA on December 15, 2015.
Bromination
of γ-cyclodexdrin 127 with the Vilsmeier-Haack reagent
prepared by reaction of bromine with triphenylphospine
in DMF gave the per-6-bromo-γ-cyclodextrin 128 in 95-98%
yield. Nucleophilic displacement of the bromines of 128
with methyl 3-mercaptopropionate (129) and cesium carbon-ate at 50°C in DMF gave 6-perdeoxy-6-per(2-methoxycarbonylethyl)
thio-γ-cyclodextrin 130 as a white powder.
Saponification of the esters of 130 was accomplished by
reaction with aqueous sodium hydroxide solution to provide
sugammadex (XVII) as a glassy solid in 52% yield for the 2
steps.
Check Digit Verification of cas no
The CAS Registry Mumber 343306-71-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,3,3,0 and 6 respectively; the second part has 2 digits, 7 and 1 respectively. Calculate Digit Verification of CAS Registry Number 343306-71: (8*3)+(7*4)+(6*3)+(5*3)+(4*0)+(3*6)+(2*7)+(1*1)=118 118 % 10 = 8 So 343306-71-8 is a valid CAS Registry Number.
343306-71-8SDS
SAFETY DATA SHEETS
According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition
Version: 1.0
Creation Date: Aug 17, 2017
Revision Date: Aug 17, 2017
1.Identification
1.1 GHS Product identifier
Product name
Org 25969
1.2 Other means of identification
Product number
-
Other names
UNII-361LPM2T56
1.3 Recommended use of the chemical and restrictions on use
Identified uses
For industry use only.
Uses advised against
no data available
1.4 Supplier's details
1.5 Emergency phone number
Emergency phone number
-
Service hours
Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).
