343306-79-6 Usage
Description
Sugammadex sodium, also known as Bridion, is an organic sodium salt that is the octasodium salt of sugammadex. It is a modified γ-cyclodextrin and belongs to the class of drugs called selective relaxant binding agents (SRBAs). Sugammadex sodium is characterized by its white to light yellow powder or crystalline appearance and is soluble in water, while being insoluble in methanol and ethanol. It is primarily used for the reversal of neuromuscular blockade induced by steroid-based muscle relaxants, such as rocuronium and vecuronium, in adults undergoing surgery.
Uses
Used in Surgical Procedures:
Sugammadex sodium is used as a reversal agent for the paralytic effects of neuromuscular blocking agents (NMB agents) in surgical procedures. It is particularly useful for facilitating tracheal intubation, mechanical ventilation, and surgical access. The drug functions as a pharmacologic sink for rocuronium and vecuronium, another non-depolarizing neuromuscular blocker, without causing the cardiovascular adverse effects associated with reversal agents that directly interact with the cholinergic system.
Used in Anesthesia:
Sugammadex sodium is used as an adjunct in anesthesia to improve the termination of the paralytic effects of NMB agents. This allows for a faster recovery and reduced time spent in the post-anesthesia care unit, leading to potential peri-operative benefits for patients.
Used in Pharmaceutical Development:
Sugammadex sodium is used as a starting point for the development of new drugs in the field of anesthesia and neuromuscular blockade reversal. Its unique properties and mechanism of action make it a valuable compound for further research and development in pharmaceutical applications.
Originator
Organon (Netherlands)
Side effects
The most common adverse effects included coughing, movement, vomiting, dry mouth, dysgeusia, hypotension, parosmia, and a sensation of changed temperature.Sugammadex is recommended for the reversal of neuromuscular blockade induced by rocuronium or vecuronium; it should not be used with other steroidal blocking agents since safety and efficacy data are not available for these situations. It should also not be partnered with non-steroidal neuromuscular blockers such as succinylcholine or benzylisoquinolinium-based drugs. Since sugammadex is predominantly cleared by the kidneys, care should be taken when administering this reversal agent in patients with renal impairment.
Check Digit Verification of cas no
The CAS Registry Mumber 343306-79-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,3,3,0 and 6 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 343306-79:
(8*3)+(7*4)+(6*3)+(5*3)+(4*0)+(3*6)+(2*7)+(1*9)=126
126 % 10 = 6
So 343306-79-6 is a valid CAS Registry Number.