34331-96-9Relevant academic research and scientific papers
Benzo[a]acridinylmethyl esters as pH sensitive fluorescent photoactive precursors: Synthesis, photophysical, photochemical and biological applications
Ikbal,Saha, Biswajit,Barman, Shrabani,Atta, Sanghamitra,Banerjee, Deb Ranjan,Ghosh, Sudip Kumar,Singh, N. D. Pradeep
, p. 3459 - 3469 (2014/05/20)
A newsworthy class of carboxylate esters based on the (benzo[a]acridin-12- yl)methyl (BAM) chromophore has been shown to perform dual functions as a "pH sensitive fluorescent probe" and a "phototrigger" for acids. The photophysical properties of all the BAM ester conjugates were investigated and found to be highly sensitive to solvent polarity, H-bonding capability and pH of the environment. On irradiation using UV light (≥410 nm), BAM ester conjugates underwent heterolytic cleavage of C-O bonds resulting in efficient release of carboxylic and amino acids. Interestingly, the newly synthesized BAM chromophore was also explored for the construction of a drug delivery system (DDS). In the current DDS, the BAM chromophore plays two important roles: (i) a "fluorophore" for cell imaging and (ii) a "phototrigger" for the drug release. In vitro biological studies revealed that the newly developed BAM based DDS has a good biocompatibility, cellular uptake properties and efficient photoregulated anticancer drug release ability. the Partner Organisations 2014.
