343311-01-3

Upstream product

• 1027089-21-9 4-(tert-butyl-dimethyl-silanyloxy)-2-(4-methylaminomethyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 228267-23-0 (2R,4R)-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxy-2-[4-(hydroxymethyl)phenyl]pyrrolidine 
• 228267-22-9 (2R,4R)-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxy-2-(4-formylphenyl)pyrrolidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 272786-44-4 (2R,4R)-2-[4-(N-tert-butoxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine 

Downstream Products

• 343311-02-4 (2R,4S)-4-acetylthio-2-[4-(N-tert-butoxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonylpyrrolidine 

Relevant academic research and scientific papers

Practical synthesis of a 1β-methylcarbapenem, J-111,225, using 4-mercapto-2-[4-(N-methylaminomethyl)phenyl]pyrrolidine as a precursor

An effective and practical procedure for the synthesis of J-111,225 (1), a new 1β-methylcarbapenem, was developed using 4-mercapto-2-[4-(N-methylaminomethyl)phenyl]pyrrolidine (2a) as a precursor. The coupling reaction of 2a with p-nitrobenzyl (PNB)-prote