343313-51-9

Upstream product

• 50910-54-8 trans-4-aminocyclohexanol hydrochloride 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 863561-77-7 C₄₁H₄₆N₆O₇S₂ 
• 667940-38-7 2-(1,1-dimethyl-2-oxo-2-(7-azabicyclo[2.2.1]heptan-7-yl)ethyl)-4-[(1S)-1-methyl-2-(N'-isopropoxycarbonyl-3-pyridin-4-yl-pyrrolidin-1-yl-carboximidamido)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrole 
• 863561-66-4 C₃₆H₅₀N₄O₄S₂ 
• 863561-51-7 3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[2-{4-(morpholin-4-ylcarbonyl)piperidin-1-yl}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole 
• 863561-74-4 C₃₈H₄₈N₄OS 
• 863561-58-4 3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[(1S)-1-methyl-2-{1-benzyl-pyrrolidin-3-ylamino}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole 
• 863561-73-3 C₃₁H₄₆N₄O 
• 1204401-34-2 N-(cis-4-iodocyclohexyl)-p-toluenesulfonamide 
• 27514-07-4 7-azabicyclo[2.2.1]heptane hydrochloride 
• 188624-92-2 7-[(4-methylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptane 

Relevant academic research and scientific papers

PYRROLE DERIVATIVES AS GONADOTROPIN RELEASING HORMONE (GNRH) ANTAGONISTS

The invention relates to a group of novel thieno-pyrrole compounds of formula (I) wherein: R1,R2, R3, R4 M, and R5 are as defined in the specification, as inter alia, gonadotrophin releasing hor

6H-THIENO`2, 3-B!PYRROLE DERIVATIVES AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE (GNRH)

The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R1, R2, R3, R4 and R5 are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.

Synthesis of N-heteroaryl-7-azabicyclo[2.2.1]heptane derivatives via palladium-bisimidazol-2-ylidene complex catalyzed amination reactions

(equation presented) A one-step approach to novel N-heteroaryl-substituted-7-azabicyclo[2.2.1]heptanes from readily available heteroaryl halides and 7-azabicyclo-[2.2.1]heptane has been achieved. The cross-coupling amination reaction employs palladium-bis