343581-95-3Relevant academic research and scientific papers
Unsymmetrical 4,6-diamino-2-methyl-5-nitropyrimidine synthesis via 4,6-bis(tosylates)
Cain, Gary A.,Beck, James P.
, p. 439 - 446 (2007/10/03)
Chlorides have traditionally been used as leaving groups for the introduction of 4- and 6-heteroatomic substituents onto pyrimidines. Use of 4,6-dichloro-2-methyl-5-nitropyrimidine allows the sequential introduction of different 4- and 6-heteroatomic substituents onto this core; however, this reagent is highly hazardous to handle. We have found that the analogous 4,6-bis(tosylate) offers a less hazardous substance which undergoes the same nucleophilic aromatic substitution chemistry as the dichloride, including sequential introduction of different nucleophiles.
