343604-03-5Relevant articles and documents
Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d]imidazole thrombopoietin mimics
Duffy, Kevin J.,Shaw, Anthony N.,Delorme, Evelyne,Dillon, Susan B.,Erickson-Miller, Connie,Giampa, Leslie,Huang, Yifang,Keenan, Richard M.,Lamb, Peter,Liu, Nannan,Miller, Stephen G.,Price, Alan T.,Rosen, Jon,Smith, Heather,Wiggall, Kenneth J.,Zhang, Lihua,Luengo, Juan I.
, p. 3576 - 3578 (2002)
The invention of a new class of naphtho[1,2-d]-imidazole thrombopoietin mimics based on a pharmacophore-hypothesis for small-molecule thrombopoietic agonists is discussed. Parallel array synthesis and purification techniques allowed for the rapid explorat